MedTrace Logo

Cognitive Strategies in Early Psychosis 1

NCT07231497 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 103

Last updated 2026-02-17

No results posted yet for this study

Summary

The goal of this clinical is to learn more about decision making in psychosis spectrum disorders, like schizophrenia. The investigators will ask people who do not have psychosis to take a single dose of modafinil and then complete some brain games on the computer that measure decision making. They hope to improve our understanding of psychosis to help people in the future. The main research questions are:

Does a single dose of modafinil change how people play the brain games? Does a single dose of modafinil change brain activity?

Participants will:

Complete an interview and self-report questionnaires. Complete safety screening activities, like a blood draw, a urine drug test, and an alcohol breathalyzer test.

Take a single dose of modafinil. Complete brain games while wearing an electroencephalography (EEG) cap, before and after taking the single dose of modafinil. EEG measures electrical activity in the brain.

Conditions

  • Cognition
  • Healthy Participants

Interventions

DRUG

Modafinil

Single dose of 200mg

Sponsors & Collaborators

Principal Investigators

  • Sophia Vinogradov, MD · University of Minnesota

  • Caroline Demro, Ph.D. · University of Minnesota

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-10-31
Primary Completion
2030-04-30
Completion
2030-04-30
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07231497 on ClinicalTrials.gov