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Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)

NCT07225660 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 394

Last updated 2026-03-02

No results posted yet for this study

Summary

HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or immediate start (without a pause).

Conditions

  • Fertility Preservation

Interventions

OTHER

OCP pause

Subjects in the study arm will be asked to discontinue combined hormonal contraceptives (CHC) for 2 months prior to planned oocyte cryopreservation

Sponsors & Collaborators

  • EMD Serono

    collaborator INDUSTRY

  • Shady Grove Fertility Reproductive Science Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-25
Primary Completion
2027-06-01
Completion
2027-07-01

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07225660 on ClinicalTrials.gov