A First-in-Human Trial of DS3790a in Participants With Hematological Malignancies
NCT07220616 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 420
Last updated 2026-05-08
Summary
This clinical trial is designed to assess the safety, preliminary efficacy, and pharmacokinetics (PK) of DS3790a monotherapy and combination regimens in participants with hematological malignancies.
Conditions
Interventions
- DRUG
-
DS3790a
Administered as specified in the protocol
- DRUG
-
Combination drug
Administered as specified in the protocol
- DRUG
-
Combination drug
Administered as specified in the protocol
Sponsors & Collaborators
- lead INDUSTRY
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-01-16
- Primary Completion
- 2030-11-30
- Completion
- 2030-11-30
- FDA Drug
- Yes
Countries
- United States
- France
- Japan
Study Locations
More Related Trials
-
SNS-301 Monotherapy in High Risk MDS and CMML
NCT04217720 ·Status: WITHDRAWN ·Phase: PHASE2
-
SB-715992 in Treating Patients With Acute Leukemia, Chronic Myelogenous Leukemia, or Advanced Myelodysplastic Syndromes
NCT00098826 ·Status: COMPLETED ·Phase: PHASE1
-
Phase I/II Trial to Investigate BI 836858 in Myelodysplastic Syndromes
NCT02240706 ·Status: TERMINATED ·Phase: PHASE2
-
Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes
NCT06484062 ·Status: RECRUITING ·Phase: PHASE1
-
A Clinical Study of BT02 in Patients With Relapsed or Refractory Hematologic Malignancies
NCT07107204 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Evaluating the Efficacy and Safety of Bemcentinib in Patients With Myelodysplastic Syndromes
NCT03824080 ·Status: COMPLETED ·Phase: PHASE2
-
Dasatinib Combination Therapy With the Smoothened (SMO) Inhibitor BMS-833923 in Chronic Myeloid Leukemia (CML)
NCT01218477 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study of Vadastuximab Talirine (SGN-CD33A; 33A) in Combination With Azacitidine in Patients With Previously Untreated Higher Risk MDS
NCT02706899 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Safety and Efficacy Study of SHR-1702 Monotherapy in Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
NCT04443751 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of E7820 in People With Bone Marrow (Myeloid) Cancers
NCT05024994 ·Status: COMPLETED ·Phase: PHASE2
-
506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment
NCT00004239 ·Status: TERMINATED ·Phase: PHASE1
-
Sequential Chemotherapy and Blinatumomab to Improve MRD Response and Survival in Acute Lymphoblastic Leukemia
NCT03367299 ·Status: COMPLETED ·Phase: PHASE2
-
Decitabine and Bortezomib in Treating Patients With Acute Myeloid Leukemia
NCT00703300 ·Status: COMPLETED ·Phase: PHASE1
-
An Efficacy Study for Epoetin Alfa in Anemic Patients With Myelodysplastic Syndromes
NCT01381809 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase I Study of MGCD0103 Given Twice Weekly in Patients With Leukemia or Myelodysplastic Syndromes
NCT00324194 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Momelotinib in Participants With Low-risk Myelodysplastic Syndrome
NCT06847867 ·Status: RECRUITING ·Phase: PHASE2
-
Discontinuation of Dasatinib in Patients With Chronic Myeloid Leukemia-CP Who Have Maintained Complete Molecular Remission for Two Years; Dasatinib Stop Trial
NCT01627132 ·Status: UNKNOWN ·Phase: PHASE2
-
Evaluation of a New Anti-cancer Immunotherapy in Adult Acute Myeloid Leukemia Patients With a Suboptimal Clinical Response to Induction Chemotherapy
NCT01051063 ·Status: COMPLETED ·Phase: PHASE1
-
Dasatinib in Treating Patients With Chronic Myelogenous Leukemia or Acute Lymphoblastic Leukemia
NCT00345826 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Dasatinib in Patients With Imatinib Resistant or Intolerant Chronic Myeloid Leukemia
NCT00866736 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase I Study of BC3402 as a Single Agent in Patients With MDS and CMML
NCT05690425 ·Status: UNKNOWN ·Phase: PHASE1
-
Evaluation of KX2-391 in Elderly Subjects With Acute Myeloid Leukemia (AML)
NCT01397799 ·Status: COMPLETED ·Phase: PHASE1
-
First-in-human Study of SAR443579 Infusion in Male and Female Children and Adult Participants With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-cell Acute Lymphoblastic Leukemia (B-ALL), High Risk-myelodysplasia (HR-MDS), or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
NCT05086315 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Clinical Trial of BP1001 (Liposomal Grb2 Antisense Oligonucleotide) in Combination With Dasatinib in Patients With Ph + CML Who Have Failed TKI, Ph+ AML, Ph+ MDS
NCT02923986 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Safety, Tolerability, PK and Efficacy of AZD1152 in Patients With Relapsed Acute Myeloid Leukemia
NCT00497991 ·Status: COMPLETED ·Phase: PHASE1