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Precision-Medicine Diagnostic Support in Hospitalized Veterans With Acute Kidney Injury

NCT07217808 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2025-10-16

No results posted yet for this study

Summary

Acute kidney injury (AKI) affects up to 20% of hospitalized Veterans and is strongly associated with morbidity and death. AKI is a diverse condition and timely and accurate diagnosis of the type of AKI is critical to begin appropriate therapies, especially those causes that require specific treatments beyond general supportive care. Yet, there are still significant gaps in the initial evaluation of AKI among hospitalized patients. Clinical decision support systems (CDSS) have shown promise to address these barriers, but most consist of simple alerting schemes and general care recommendations provided at a single point in time. The goal of this proposal is to develop and test the feasibility and usability of a rule-based and Artificial Intelligence-assisted precision CDSS tool (PRECISE-AKI) that can provide cognitive support to improve timely initial diagnostic evaluation of AKI.

Conditions

  • Acute Kidney Injury (AKI)

Interventions

OTHER

PRECISE-AKI Clinical Decision Support Tool

The Intervention arm will consist of Clinical Decision Diagnostic Support (CDS) provided by the PRECISE-AKI tool

Sponsors & Collaborators

  • VA Tennessee Valley Health Care System

    collaborator FED

  • Vanderbilt University Medical Center

    collaborator OTHER

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • Edward D Siew, MD MSc · Tennessee Valley Healthcare System Nashville Campus, Nashville, TN

  • Michael E Matheny, MD MS MPH · Tennessee Valley Healthcare System Nashville Campus, Nashville, TN

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2028-01-01
Primary Completion
2028-12-31
Completion
2029-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07217808 on ClinicalTrials.gov