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Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans

NCT07216781 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2026-02-17

No results posted yet for this study

Summary

The purpose of this study is to investigate the safety and efficacy of a gene therapy for Klotho, delivered via a nonviral plasmid in healthy adult volunteers. Additionally, this study seeks to understand the cognitive and health benefits of the Klotho gene therapy.

Conditions

  • Healthy Adults

Interventions

GENETIC

Injectable Plasmid Klotho Gene Therapy

Injection of plasmid-delivered Klotho gene therapy

Sponsors & Collaborators

  • Minicircle

    lead INDUSTRY

Study Design

Allocation
NA
Purpose
PREVENTION
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
23 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-10-06
Primary Completion
2026-08-31
Completion
2026-08-31

Countries

  • United States
  • Honduras

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07216781 on ClinicalTrials.gov