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Analysis of Clinical Outcomes in Patients Undergoing Magnetic Resonance-Guided Focused Ultrasound for Medication-Refractory Tremor

NCT07212244 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 240

Last updated 2025-10-08

No results posted yet for this study

Summary

The goal of this observational study is to evaluate the long-term efficacy and safety of MR-guided focused ultrasound (MRgFUS) thalamotomy in patients with medication-refractory essential tremor.

The main questions it aims to answer are:

1. Does MRgFUS thalamotomy provide sustained reduction in tremor severity over 3 years?
2. What are the long-term neurological and quality-of-life outcomes associated with this procedure?

Participants will:

* Undergo MRgFUS thalamotomy as part of standard of care at Sunnybrook Health Sciences Centre.
* Be followed prospectively for a minimum of 3 years with scheduled assessments including:

1. Clinical Rating Scale for Tremor (CRST)
2. Neurological exams and adverse event monitoring
3. Quality of Life in Essential Tremor (QUEST) questionnaire
4. Scale for the Assessment and Rating of Ataxia (SARA)
5. MRI imaging and neuropsychological testing

Conditions

Sponsors & Collaborators

  • Sunnybrook Health Sciences Centre

    lead OTHER

Eligibility

Min Age
22 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-31
Primary Completion
2031-09-30
Completion
2032-09-30

Countries

  • Canada

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07212244 on ClinicalTrials.gov