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Protein A Immunoadsorption in Highly Sensitized Haplo-HSCT Patients

NCT07200583 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2025-11-18

No results posted yet for this study

Summary

This study reviews patients who received haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Some patients develop donor-specific antibodies (DSA), which can block engraftment and cause transplant failure. Before transplant, a treatment called protein A immunoadsorption (a blood purification method to remove antibodies) was used, sometimes with additional medications.

The study aims to see whether this approach lowers antibody levels, increases the chance of successful engraftment, reduces complications such as infections or graft failure, and improves short-term survival. The results may help guide safer and more effective transplants for highly sensitized patients.

Conditions

  • Hematologic Malignancies
  • Hematologic Disorders
  • Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
  • Graft Failure

Interventions

PROCEDURE

Protein A immunoadsorption

Extracorporeal therapy performed prior to haploidentical HSCT to remove donor-specific anti-HLA antibodies (DSA)

DRUG

Rituximab (optional, in some patients)

Anti-CD20 monoclonal antibody occasionally combined with immunoadsorption as part of desensitization strategy

DRUG

Bortezomib (optional, in some patients)

Proteasome inhibitor occasionally used in combination with desensitization therapy.

Sponsors & Collaborators

  • Ting YANG

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-31
Primary Completion
2025-08-31
Completion
2025-08-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07200583 on ClinicalTrials.gov