Clinical Study of BCMA/CD70-targeted CAR-T Therapy for Refractory Pediatric Rheumatic Diseases
NCT07184450 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 11
Last updated 2025-09-19
Summary
This is an investigator-initiated trial to evaluate the efficacy and safety of BCMA/CD70-targeted CAR-T in the treatment of refractory pediatric rheumatic diseases.
Conditions
- Juvenile Dermatomyositis (JDM)
- Polyarticular Juvenile Idiopathic Arthritis
- Systemic Sclerosis (SSc)
- Primary Sjogren's Syndrome
Interventions
- BIOLOGICAL
-
BCMA/CD70-targetd CAR-T
Subjects underwent lymphocytetion cheotherapy and then received a single intravenous cell infusion
Sponsors & Collaborators
-
Chongqing Precision Biotech Co., Ltd
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 5 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-09-01
- Primary Completion
- 2026-03-30
- Completion
- 2028-09-30
Countries
- China
Study Locations
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