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Menstrual Cycle TMS Plasticity Pilot

NCT07180654 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2026-01-09

No results posted yet for this study

Summary

Aim 1: Assess how menstrual cycle phase affects motor cortex plasticity in females.

Aim 2: Compare motor cortex plasticity between males and females across the same time points, identifying potential sex differences in TMS response.

Aim 3: Examine associations between serum hormone levels and TMS-induced plasticity within and between sexes.

Conditions

  • Cortical Activation

Interventions

DEVICE

transcranial magnetic stimulation

Subjects will receive a series of 60 10s trains that will be presented over the course of the \~3.5 min session. Each train will consist of 2 s of stimulation with an 8 s ITI. During the 2 s of stimulation, 10, 50 Hz bursts will be repeated at intervals of 200 ms (5 Hz). iTBS will be administered at 100% of the motor threshold (MT).

Sponsors & Collaborators

Principal Investigators

  • Nicholas Balderston, PhD · University of Pennsylvania

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-12-15
Primary Completion
2028-10-31
Completion
2028-10-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07180654 on ClinicalTrials.gov