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A Comparative Study of Endoscopic Choanal Canalization and Mitomycin C Application vs Endoscopic Crossover Flap Technique

NCT07173023 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-09-15

No results posted yet for this study

Summary

determine the optimal surgical strategy for achieving

1. long-term outcomes
2. minimizing complications
3. improving outcomes in CCA patients

Conditions

  • Choanal Atresia

Interventions

PROCEDURE

Transnasal Puncture with Mitomycin C application

* Performed under general anesthesia. * Nasal cavities decongested with oxymetazoline. * Atretic plate perforated using serial dilators under direct visualization. * Additional removal of bony/membranous tissue including the posterior nasal septum as possible. * Topical mitomycin C (0.5 mg/mL) applied to the edges of the newly created choana for 2 minutes using cotton pledget in a transparent tube , followed by irrigation with saline. * syndromatic patients and patients requiring less time UGA will be included in this group

PROCEDURE

Endoscopic Crossover Flap Repair

* Performed under general anesthesia using a 0° 4 mm endoscope. * Elevation of mucosal crossover flaps to cover exposed bone following resection of the atretic plate where one flap is inferiorly based and the other is superiorly based. * Precise removal of the posterior vomer and lateral bony plates as needed using cold steel instruments and possible nasal drill. * Flaps will be repositioned to minimize exposed bone and promote mucosal healing preventing restenosis.

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Principal Investigators

  • ebram hamdy dawood, resident doctor · Assiut University

  • Moustafa omar Mohammed Ali, lecturer · Assiut University

  • ezzat mohammed saleh, professor doctor · Assiut University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
0 Months
Max Age
72 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-30
Primary Completion
2027-09-30
Completion
2028-09-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07173023 on ClinicalTrials.gov