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Prognostic Score Comparison in IPF and HP

NCT07169253 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 143

Last updated 2025-09-11

No results posted yet for this study

Summary

The goal of this retrospective observational study is to evaluate and compare the prognostic value of GAP, ILD-GAP, and CPI scoring systems in patients diagnosed with interstitial lung diseases (ILDs), specifically Idiopathic Pulmonary Fibrosis (IPF), fibrotic Hypersensitivity Pneumonitis, and non-fibrotic Hypersensitivity Pneumonitis.

The main questions it aims to answer are:

* Can GAP, ILD-GAP, and CPI scores accurately predict prognosis in IPF, fibrotic HP, and non-fibrotic HP patients?
* Are there differences in prognostic performance of these models across different ILD subtypes?

Researchers will compare the prognostic utility of GAP, ILD-GAP, and CPI scores between IPF, fibrotic HP, and non-fibrotic HP groups to see if one scoring system offers superior predictive power.

Participants:

* Adults aged ≥18 years
* Diagnosed between October 2011 and October 2021 at the University of Health Sciences Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital
* 143 patients in total (IPF: 45, fibrotic HP: 26, non-fibrotic HP: 72)

Participants' data will include:

* Clinical and demographic characteristics
* Symptom duration
* Radiologic imaging findings
* Pulmonary function test (PFT) results
* Bronchoalveolar lavage (BAL) findings
* Histopathological diagnoses

Scoring systems will be calculated using standardized formulas as follows:

* GAP (Gender, Age, Physiology)
* ILD-GAP (modified GAP for CTD-ILDs)
* CPI (Composite Physiologic Index = 91 - \[0.65 × %DLCO\] - \[0.53 × %FVC\] + \[0.34 × %FEV1\])

Conditions

  • IPF
  • Fibrotic Lung Disease
  • Hypersensitivity Pneumonitis
  • Interstitial Lung Disease (ILD)

Interventions

OTHER

GAP Index

For each patient in the IPF, fibrotic HP, and non-fibrotic HP groups, the GAP index was calculated based on age, gender, FVC, and DLCO values. According to the GAP index, patients were classified as Stage 1 (0-3 points), Stage 2 (4-5 points), and Stage 3 (6-8 points).

OTHER

ILD-GAP Index

In addition to the GAP parameters, the index was calculated to include the ILD subtype as well.

OTHER

Composite Physiologic Index (CPI)

The CPI (Composite Physiologic Index) was calculated using the following formula: CPI = 91 - (0.65 × %DLCO) - (0.53 × %FVC) + (0.34 × %FEV1). DLCO: Diffusing Capacity of the Lung for Carbon Monoxide FVC: Forced Vital Capacity FEV₁: Forced Expiratory Volume in One Second

Sponsors & Collaborators

  • Saglik Bilimleri Universitesi

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-01
Primary Completion
2023-02-01
Completion
2023-03-01

Countries

  • Turkey (Türkiye)

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07169253 on ClinicalTrials.gov