Study of Allogeneic Anti-PSMA CAR-NK Cell for Metastatic Castration-Resistant Prostate Cancer
NCT07156045 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 10
Last updated 2026-01-23
Summary
At present, no cell drug with an indication for mCRPC has been approved for marketing in China, and there is no scholar to fight against it PSMA-CAR-NK cell therapy CRPC was reported in a study. Based on the previous basic research, our company has developed CAR-NK cell injection, hoping to further evaluate its safety, tolerability and preliminary efficacy in the treatment of mCRPC patients in clinical studies, and provide new possibilities for the selection of clinical treatment strategies
Conditions
- Prostate Cancer Castration-resistant Prostate Cancer
Interventions
- BIOLOGICAL
-
anti-PSMA CAR-NK
Targeting PSMA CAR-NK cells
Sponsors & Collaborators
-
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- MALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-09-01
- Primary Completion
- 2026-12-31
- Completion
- 2026-12-31
Countries
- China
Study Locations
More Related Trials
-
A Study Evaluating [177Lu]Lu-PSMA-617 vs. a Change of Androgen Receptor-directed Therapy in Taxane Treatment Naive Chinese Male Patients With Progressive Metastatic Castrate Resistant Prostate Cancer
NCT05658003 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Evaluating the Safety and Efficacy of 177Lu-LNC1011 Injection in a Single-Center, Single-Arm, Open Study in Patients with Prostate-Specific Membrane Antigen (PSMA)-Positive Metastatic Desmoplasia-Resistant Prostate Cancer
NCT06809426 ·Status: COMPLETED ·Phase: NA
-
TmPSMA-02 in mCRPC
NCT06046040 ·Status: RECRUITING ·Phase: PHASE1
-
A Clinical Study Evaluating the Safety and Efficacy of Local Injection of ACT#001 Chimeric Antigen Receptor T Cells in the Treatment of Castration-Resistant Prostate Cancer
NCT07240857 ·Status: ENROLLING_BY_INVITATION ·Phase: EARLY_PHASE1
-
Prospective Clinical Trial of 225Ac-LNC1011 in the Treatment of Metastatic Castration-Resistant Prostate Cancer
NCT07117760 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
CART-PSMA Cells for Advanced Prostate Cancer
NCT05656573 ·Status: RECRUITING ·Phase: PHASE1
-
A Clinical Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of [225Ac]Ac-PSMA-XT Injection in Patients With Metastatic Castration-resistant Prostate Cancer
NCT07135102 ·Status: RECRUITING ·Phase: PHASE1
-
Clinical Study of Safety and Efficacy of Enhanced PSMA CAR- T in Refractory CRPC
NCT06228404 ·Status: ACTIVE_NOT_RECRUITING ·Phase: EARLY_PHASE1
-
Clinical Evaluation of 177Lu-DansyI-PSMA (LNC1011) in Patients With Metastatic Castration-Resistant Prostate Cancer
NCT06377683 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of CART-PSMA-TGFβRDN in Patients With Metastatic Castration Resistant Prostate Cancer
NCT04227275 ·Status: TERMINATED ·Phase: PHASE1
-
Study of 177Lu-PSMA-0057 in Metastatic Prostate Cancer
NCT06050239 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
177Lu-PSMA-I&T for Metastatic Castration-Resistant Prostate Cancer
NCT05204927 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
177Lu-PSMA-617 in Metastatic Castration Resistant Prostate Cancer (mCRPC) With Bone Marrow Involvement and Cytopenia
NCT07025512 ·Status: WITHDRAWN ·Phase: PHASE2
-
Fractionated and Multiple Dose 225Ac-J591 for Progressive mCRPC
NCT04506567 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Study of TYK-00540 Combined With Enzalutamide in Patients With Metastatic Castration-resistant Prostate Cancer(mCRPC)
NCT07104643 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
PD-1 Silent PSMA/PSCA Targeted CAR-T for the Treatment of Prostate Cancer
NCT05732948 ·Status: UNKNOWN ·Phase: PHASE1
-
A Safety Study of JNJ-56021927 in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT02162836 ·Status: COMPLETED ·Phase: PHASE1
-
PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer
NCT05805371 ·Status: RECRUITING ·Phase: PHASE1
-
P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) and Advanced Salivary Gland Cancers (SGC)
NCT04249947 ·Status: TERMINATED ·Phase: PHASE1
-
Clinical Trial of Targeted Alpha Therapy Using [At-211]PSMA-5 for Prostate Cancer
NCT06441994 ·Status: RECRUITING ·Phase: PHASE1
-
Study to Assess the Treatment Patterns in Metastatic Castration-Resistance Prostate Cancer (mCRPC)
NCT02230059 ·Status: COMPLETED
-
Phase I/II Study of [225Ac]Ac-PSMA-R2 in PSMA-positive Prostate Cancer, With/Without Prior 177Lu-PSMA RLT
NCT05983198 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
The Safety and Dosimetry Study of 177Lu-LNC1003 Injection
NCT06237491 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
A Phase II Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of YL201 in Patients With mCRPC
NCT06241846 ·Status: RECRUITING ·Phase: PHASE2
-
First-Time-in-Human Study of GSK5471713 in Adults With mCRPC
NCT07332455 ·Status: RECRUITING ·Phase: PHASE1/PHASE2