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Innovative Treatments for Neurogenic Dysphagia

NCT07152899 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 110

Last updated 2025-09-03

No results posted yet for this study

Summary

This study aims to evaluate different non-invasive and neuromuscular stimulation treatments for neurogenic dysphagia in post-stroke and Parkinson's disease patients. The study is divided into three sub-studies:

1. Unilateral, bihemispheric, or sham transcranial Direct Current Stimulation (tDCS) in post-stroke dysphagia (patients ≥2 weeks from onset).
2. Bihemispheric or sham tDCS in Parkinson's disease-related dysphagia.
3. Neuromuscular stimulation therapy in post-stroke and Parkinson's disease dysphagia.

Conditions

Interventions

OTHER

Unilateral anodal tDCS

Evaluates the effects of unilateral, anodal tDCS applied to the swallowing motor cortex in post-stroke patients with dysphagia

OTHER

Bihemispheric anodal tDCS

Evaluates the effects of bihemispheric, anodal tDCS applied to the swallowing motor cortex in post-stroke patients with dysphagia and in Parkinson's disease-related dysphagia

OTHER

Sham tDCS

Evaluates the effects of Sham tDCS applied to the swallowing motor cortex in post-stroke patients with dysphagia and in Parkinson's disease-related dysphagia

OTHER

NMES + swallowing therapy

Examines the effects of NMES therapy on swallowing function in both post-stroke and Parkinson's disease patients

OTHER

Sham NMES + swallowing therapy

Examines the effects of Sham therapy on swallowing function in both post-stroke and Parkinson's disease patients

Sponsors & Collaborators

  • ASST Santi Paolo e Carlo

    collaborator OTHER

  • L. Sacco Department of Biomedical and Clinical Sciences, Milano, Italy

    collaborator UNKNOWN

  • Fondazione Don Carlo Gnocchi Onlus

    collaborator OTHER

  • Istituti Clinici Scientifici Maugeri SpA

    collaborator OTHER

  • IRCCS National Neurological Institute "C. Mondino" Foundation

    lead OTHER

Principal Investigators

  • Giuseppe Cosentino, MD · Translational Neurophysiology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-15
Primary Completion
2025-01-15
Completion
2025-05-15

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07152899 on ClinicalTrials.gov