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Probiotic Nanofiber Floss and Subgingival Pathogen Suppression

NCT07149493 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 33

Last updated 2025-09-02

No results posted yet for this study

Summary

This randomized, double-blind, crossover clinical trial evaluated the effect of a probiotic-containing nanofiber dental floss on subgingival red complex periopathogens and gingival health in periodontally healthy individuals. Thirty male participants underwent two 14-day flossing interventions (probiotic floss and placebo floss), separated by a 14-day washout period. Clinical and microbiological parameters were assessed using standardized indices and multiplex qPCR.

This study was conducted prospectively but is being registered retrospectively to ensure transparency and compliance with NIH guidelines.

Conditions

  • Dental Hygiene
  • Probiotics, Periodontitis
  • Prevention of Dental Caries
  • Gingivitis and Periodontal Diseases
  • Periodontal Health
  • Oral Microbiome

Interventions

DEVICE

Placebo nanofiber floss

Identical floss without probiotic coating, used under the same conditions.

DEVICE

Probiotic nanofiber floss

Nanofiber floss infused with Ligilactobacillus salivarius (strain BCRC 14759), used twice daily for 14 days.

Sponsors & Collaborators

  • Czech Technology Agency

    collaborator UNKNOWN

  • Ministry of Health, Czech Republic

    collaborator OTHER_GOV

  • RECETOX

    collaborator UNKNOWN

  • The University Hospital Brno

    collaborator UNKNOWN

  • St. Anne's University Hospital Brno, Czech Republic

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-02-01
Primary Completion
2022-06-24
Completion
2022-06-24

Countries

  • Czechia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07149493 on ClinicalTrials.gov