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Retinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS)

NCT07146516 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 500

Last updated 2026-05-26

No results posted yet for this study

Summary

The goal of this clinical trial is to prospectively document to what extent the OSC/SS prophylactic laser retinopexy procedure works to prevent retinal detachment in SS in children and adults.

Researchers will compare the OSC/SS procedure in SS to the natural progression of SS to see to what extent the OSC/SS procedure works to prevent retinal detachment.

Participants will:

* Have the OSC/SS procedure in one or both eyes
* Have eye tests
* Have genetic testing for SS as needed
* Visit the study center 9 times over 5 years for checkups and tests
* Have data for the untreated fellow-eye collected and used as study data if available

Conditions

  • Stickler Syndrome Type 1
  • Stickler Syndrome Type 2

Interventions

PROCEDURE

Prophylactic (non-invasive) Laser Retinopexy

Prophylactic laser retinopexy to prevent RD in participants with SS using the indirect ophthalmoscopy (IDO) to place approximately 1500 to 2500 moderate intensity burns to produce encircling grid pattern, placed one burn width apart from 2 MM anterior to the ora serrata, extending to and between the vortex vein ampullae.

Sponsors & Collaborators

  • Five Lakes Clinical Research Consulting, LLC

    collaborator UNKNOWN

  • Helen Keller Eye Research Foundation

    lead OTHER

Principal Investigators

  • Robert E Morris, MD · Helen Keller Eye Research Foundation

  • Peter J Belin, MD · Retina Consultants of Minnesota

Study Design

Allocation
NA
Purpose
PREVENTION
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-30
Primary Completion
2035-12-31
Completion
2035-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07146516 on ClinicalTrials.gov