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The Effect of Perioperative Hyperglycemia on Anastomotic Leaks After Total Gastrectomy

NCT07140991 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 102

Last updated 2025-08-26

No results posted yet for this study

Summary

Esophagojejunostomy anastomosis is used in total gastrectomy surgeries. Anastomotic leakage is a serious complication seen after these surgeries and is associated with increased morbidity and mortality. Patients with older age and comorbidities have a higher risk of death following anastomotic leakage.

Perioperative hyperglycemia is frequently observed in patients undergoing major abdominal surgery as a stress response to surgical trauma, leading to surgical complications through mechanisms such as glycogenolysis, lipolysis, gluconeogenesis, decreased insulin sensitivity, and increased insulin resistance. Hyperglycemia is known to increase the risk of postoperative infection, prolong hospital stay, and increase mortality. Additionally, recent studies have shown that it also increases the risk of anastomotic leakage.

Conditions

  • Hyperglycaemia
  • Total Gastrectomy
  • Anastomotic Leaks

Sponsors & Collaborators

  • Taner Abdullah

    lead OTHER

Principal Investigators

  • Mustafa Çağrı Temel, MD · Basaksehir Cam ve Sakura State Hospital

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-01
Primary Completion
2025-07-20
Completion
2025-08-20

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07140991 on ClinicalTrials.gov