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Effect of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA) on Gastric Emptying

NCT07140289 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-09-03

No results posted yet for this study

Summary

This study aims to assess the effect of using Glucagon-like peptide-1 receptor agonists (GLP-1) receptor agonists on gastric emptying on surgical patients and whether specific guidelines need to be established for these patients. GLP-1 receptor agonists are mainly used for the treatment and mitigation of obesity and metabolic syndromes. One of their mechanisms of action is by delaying gastric emptying, hence increasing satiety. However, patients need to abstain from eating for a set amount of time before surgery to reduce the risk of aspiration. Hence patients who use GLP-1 receptor agonists may need more time to abstain eating (nil-per-os). In this study we aim to assess how much time is sufficient before surgery in these specific population of patients.

Conditions

  • Gastric Emptying
  • Glucagon-Like Peptide-1 Receptor Agonists
  • Intermittent Fasting
  • Intraoperative Complication Due to Anesthesia
  • Respiratory Aspiration of Gastric Contents

Interventions

DIAGNOSTIC_TEST

Ultrasound of gastric contents

An ultrasound examination of the abdomen to observe and measure gastric contents

Sponsors & Collaborators

  • Wayne State University

    collaborator OTHER

  • Wael Saasouh, MD

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-09-01
Primary Completion
2027-06-01
Completion
2028-06-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07140289 on ClinicalTrials.gov