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Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery

NCT07140172 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1060

Last updated 2026-05-11

No results posted yet for this study

Summary

This trial is to investigate if in patients with clinically node positive breast cancer undergoing upfront surgery, treatment with TAS and ART is superior to ALND in terms of arm-related Quality of Life (QoL) and occurrence of lymphedema two years after randomization.

Conditions

Interventions

PROCEDURE

Axillary lymph node dissection (ALND)

Surgical removal of lymphatic tissue within the anatomical boundaries of the axilla (standard of care in the upfront surgery setting in patients with cN+ BC)

PROCEDURE

Axillary radiotherapy (ART)

Axillary irradiation

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Walter P. Weber, Prof. Dr. med. · Breast Surgery Service, University Hospital Basel

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-01
Primary Completion
2029-12-31
Completion
2037-12-31

Countries

  • United States
  • Austria
  • Canada
  • Croatia
  • Germany
  • Greece
  • Ireland
  • Italy
  • Latvia
  • Switzerland
  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07140172 on ClinicalTrials.gov