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Distal vs Conventional Transradial Access for Coronary Procedures

NCT07138170 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 350

Last updated 2026-05-11

No results posted yet for this study

Summary

Background: Radial artery occlusion (RAO) is a recognized complication of transradial coronary access, with reported incidence rates ranging from 5% to 30%. Distal radial access (DRA), performed at the anatomical snuffbox, has emerged as a promising alternative that may better preserve radial artery patency by maintaining antegrade perfusion through the palmar arch during hemostasis.

Objective: To compare distal radial access with conventional transradial access in terms of radial artery patency and access-site outcomes in a real-world all-comers population undergoing coronary angiography or percutaneous coronary intervention.

Methods: This prospective, multicenter, open-label, quasi-randomized comparative study enrolled 350 patients across three community-based hospitals in Palestine and Jordan between 2024 and 2026. Patients were allocated in a 1:1 ratio to DRA (n=183) or conventional transradial access (n=167) using an alternating sequence. The primary endpoint was radial artery patency assessed by blinded duplex ultrasonography at 24 hours and at 1 to 6 months. Secondary endpoints included access-site pain, bruising, numbness, and crossover to an alternative access site. The 24-hour outcome was analyzed by intention-to-treat and long-term outcomes by per-protocol analysis. Adjusted analyses used Firth penalized logistic regression.

Conditions

  • Radial Artery Occlusion Following Coronary Catheterization

Interventions

PROCEDURE

Conventional Transradial Artery Access

Using Conventional Transradial Artery Access for Cardiac Catheterization

PROCEDURE

Distal Radial Artery Access

Using Distal Radial Artery access for Cardiac Catheterization

Sponsors & Collaborators

  • Jordanian Research and Artificial Intelligence Group

    lead OTHER

Principal Investigators

  • Mahmoud Izraiq, Medical Doctor · The Specialty Hospital

  • Raed Aqel, Medical Doctor · Al-Mezan Medical Center

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-15
Primary Completion
2026-02-15
Completion
2026-04-29

Countries

  • Jordan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07138170 on ClinicalTrials.gov