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Spleen Volume Change Predicts 45-Day Mortality in Neurocritical Care: A Prospective Cohort Study

NCT07132996 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 42

Last updated 2025-08-20

No results posted yet for this study

Summary

This study investigates whether changes in spleen size over 72 hours can help predict the risk of death within 45 days in patients who were admitted to the emergency department with a type of bleeding in the brain called intracerebral hemorrhage. The spleen is a key immune organ that may shrink or enlarge in response to injury. A total of 42 adult patients with confirmed intracerebral hemorrhage were enrolled between March and September 2024 at Ankara Bilkent City Hospital in Turkey. Spleen size and brain bleeding volume were measured by imaging tests at the time of admission and repeated 72 hours later. Patients were followed for 45 days to determine survival status. The main goal of the study was to see if spleen size change (ΔSpleen) is a better predictor of death than brain bleeding volume change (ΔHematoma).

Conditions

  • Intracerebral Hemorrhage (ICH)
  • Hemorrhagic Stroke, Intracerebral
  • Neurocritical Care
  • Acute Brain Injury
  • Ultrasound

Interventions

DIAGNOSTIC_TEST

POCUS-based Splenic Volume Measurement

Splenic volume was measured at baseline and at 72 hours using the Butterfly iQ+ handheld ultrasound (Butterfly Network, Inc.) in abdominal preset mode. Certified POCUS operators obtained spleen length, width, and depth in standard orthogonal planes. Volumes were calculated using the prolate ellipsoid formula (length × width × depth × 0.523), a validated method in ultrasound volumetric studies. ΔSpleen was defined as the 72-hour value minus the baseline value.

Sponsors & Collaborators

  • Ankara City Hospital Bilkent

    lead OTHER

Principal Investigators

  • Cagdas Yildirim, Assistant Professor · Ankara City Hospital Bilkent

  • Kadir Yenal, Attending Physician · Ankara City Hospital Bilkent

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-03-15
Primary Completion
2024-09-15
Completion
2024-10-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07132996 on ClinicalTrials.gov