Comparing the Efficacy and Safety of Chemotherapy Combined With or Without Immunotherapy as an Adjuvant Treatment After Radical Surgery for Patients With Resectable Adenocarcinoma of the Esophagogastric Junction of Gastric Cancer
NCT07132528 · Status: NOT_YET_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 1000
Last updated 2025-08-20
Summary
This study is to evaluate the efficacy and safety of chemotherapy combined with or without Immunotherapy as an Adjuvant Treatment After Radical Surgery for Patients With Resectable Adenocarcinoma of the Esophagogastric Junction of Gastric Cancer
Conditions
- Gastric / Gastroesophageal Junction Adenocarcinoma
Interventions
- DRUG
-
SOX plus PD-1 inhibitor
SOX or XELOX plus PD-1 inhibitor
- DRUG
-
SOX Chemotherapy
SOX or XELOX
Sponsors & Collaborators
-
Liaoning Cancer Hospital & Institute
lead OTHER
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-08-31
- Primary Completion
- 2028-03-31
- Completion
- 2028-09-30
More Related Trials
-
Tislelizumab Combined with SOX Regimen in the Treatment of Locally Advanced Gastric Cancer/gastroesophageal Junction Adenocarcinoma
NCT06764251 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Phase II Trial of Perioperative Adebrelimab Combined With XELOX in Resectable Locally Advanced Gastric/Gastroesophageal Junction Cancer (GC/GEJC)
NCT06506292 ·Status: RECRUITING ·Phase: PHASE2
-
SOX as Adjuvant Chemotherapy for Resectable Gastric Cancer
NCT01542294 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Clinical Study of Low-dose Interval Radiotherapy Combined With Tirelizumab and SOX Chemotherapy Neoadjuvant Therapy for Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma
NCT06766578 ·Status: RECRUITING ·Phase: PHASE2
-
QL1706 Combined With SOX Used in Theperioperative Treatment
NCT06766305 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Neoadjuvant Apatinib Combined With Sintilimab and Perioperative SOX Versus Neoadjuvant Sintilimab Combined With Perioperative SOX for Intestinal Type of Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma
NCT06925243 ·Status: RECRUITING ·Phase: PHASE3
-
To Evaluate the Efficacy and Safety of Cadonilimab With SOX as Neoadjuvant Therapy for Resectable Locally Advanced Gastric or Gastroesophageal Junction Adenocarcinoma.
NCT05948449 ·Status: UNKNOWN ·Phase: PHASE2
-
Neoadjuvant Immunotherapy and Chemotherapy for Locally Advanced Esophagogastric Junction and Gastric Cancer Trial
NCT04744649 ·Status: UNKNOWN ·Phase: PHASE2
-
Preoperative Concurrent Chemoradiotherapy for Potentially Resectable Adenocarcinoma of the Esophagogastric Junction
NCT01962246 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
A Randomized Phase II Trial of Neoadjuvant Chemotherapy Compared With Chemoradiotherapy in Gastric Adenocarcinoma
NCT02301481 ·Status: COMPLETED ·Phase: PHASE2
-
Camrelizumab Combined With or Without Apatinib and SOX of Neoadjuvant Treatment for Gastric Cancer
NCT06693128 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Efficacy and Safety of Neoadjuvant Nivolumab Plus SOX Versus Nivolumab Plus FLOT in Patients With HER2-negative Gastric and Gastroesophageal Junction Adenocarcinoma
NCT06440811 ·Status: COMPLETED
-
Neoadjuvant Chemotherapy Plus Chemoradiation in Patients With Potentially Resectable Gastric Carcinoma
NCT02024217 ·Status: UNKNOWN ·Phase: PHASE2
-
First-Line and Neoadjuvant Immunotherapy for Gastric Cancer
NCT06727981 ·Status: RECRUITING
-
Tirelizumab Combined With Chemotherapy in the Treatment of HER-2 Negative Locally Advanced Gastric Cancer
NCT06284746 ·Status: RECRUITING ·Phase: PHASE2
-
Efficacy and Safety of Serplulimab Combined With Chemotherapy as Neoadjuvant Treatment for Locally Advanced Gastric Cancer or Adenocarcinoma of Esophagogastric Junction
NCT06576921 ·Status: RECRUITING ·Phase: PHASE2
-
A Comparison of XELOX Regimen and EOX Regimen as Neoadjuvant Chemotherapy Regimen for Locally Advanced Gastric Cancer.
NCT02192983 ·Status: COMPLETED
-
Evaluation of the Efficacy and Safety of Adebrelimab Combined With SOX as Adjuvant Therapy for IIIB and IIIC Gastric Cancer
NCT07033143 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Efficacy of Perioperative Chemotherapy Plus PD-1 Antibody in the Locally Advanced Gastric Cancer
NCT04250948 ·Status: UNKNOWN ·Phase: PHASE2
-
A Phase II Study of Total Neoadjuvant Therapy for Locally Advanced Gastric Cancer
NCT04062058 ·Status: UNKNOWN ·Phase: PHASE2
-
Tumor Microenvironment in Gastric Cancer Patients Treated With Combined Immunotherapy and Chemotherapy
NCT06202781 ·Status: RECRUITING
-
Clinical Study of Camrelizumab Combined With SOX in the Adjuvant Treatment of Advanced Gastric Adenocarcinoma or Gastric Esophageal Junction Adenocarcinoma
NCT05184946 ·Status: UNKNOWN ·Phase: PHASE2
-
S-1 and Oxaliplatin (SOX) Plus Sintilimab in the Locally Advanced Esophagogastric Junction Adenocarcinoma
NCT04989985 ·Status: RECRUITING ·Phase: PHASE2
-
Transarterial Neoadjuvant Chemotherapy vs.Traditional Intravenous Chemotherapy For Locally Advanced Gastric Cancer With SOX+PD-1
NCT05593458 ·Status: RECRUITING ·Phase: PHASE3
-
Tislelizumab Combined With S-1 Plus Oxaliplatin as a Neoadjuvant Treatment in Patients With GC/GEJC
NCT04890392 ·Status: UNKNOWN ·Phase: PHASE2