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Stratification, Management, and Guidance of Hypertrophic Cardiomyopathy Patients Using Hybrid Digital Twin Solutions

NCT07131371 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 2500

Last updated 2025-08-27

No results posted yet for this study

Summary

The goal of SMASH-HCM is to develop a digital twin or virtual model of the heart and vascular system with sympathetic nerve control that integrates multi-scale and multi-organ spatiotemporal biophysical data from a multitude of sources. SMASH-HCM's digital twin powered platform will dramatically improve hypertrophic cardiomyopathy (HCM) patient stratification and disease management through stepwise deep phenotyping integrated in clinical and patient-guided workflows.

Conditions

  • HCM - Hypertrophic Cardiomyopathy

Sponsors & Collaborators

  • University of Bologna

    collaborator OTHER

  • Universita Degli Studi di Firenze

    collaborator UNKNOWN

  • Rennes University Hospital

    collaborator OTHER

  • University of Milan

    collaborator OTHER

  • University College Dublin

    collaborator OTHER

  • Universitätsklinikum Hamburg-Eppendorf

    collaborator OTHER

  • Medtronic Bakken Research

    collaborator INDUSTRY

  • Pharmatics Limited

    collaborator UNKNOWN

  • University of Oxford

    collaborator OTHER

  • University of Rennes 2

    collaborator OTHER

  • Tampere University

    lead OTHER

Principal Investigators

  • Jari Hyttinen, Professor · Professor

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-15
Primary Completion
2026-12-31
Completion
2028-12-31

Countries

  • Finland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07131371 on ClinicalTrials.gov