Metabolic Risk Assessment in Prepubertal Children With Congenital Hypothyroidism

Summary

We propose a multicenter prospective study to define the prevalence and severity score of metabolic syndrome in a prepubertal pediatric cohort with congenital hypothyroidism, compared to a healthy and normal-weight pediatric population. These data will help to define whether hypothyroidism can be considered a risk factor for the metabolic health of the pediatric population. The possible identification of an at-risk metabolic profile will provide useful information to optimize the diagnostic and monitoring pathway for affected children.

Conditions

• Congenital Hypothyroidism
• Metabolic Syndrome

Interventions

OTHER

prospective observational study (clinical, hormonal and auxological data)

We collect clinical, hormonal and auxological data and compare them between the two groups.

Sponsors & Collaborators

• Federico II University

  collaborator OTHER

• IRCCS Ospedale San Raffaele

  collaborator OTHER

• Policlinico di Bari Giovanni XXIII

  collaborator UNKNOWN

• Azienda Ospedaliero Universitaria Policlinico Modena

  collaborator OTHER

• Azienda Ospedaliero-Universitaria di Parma

  collaborator OTHER

• Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna

  collaborator OTHER

• Azienda Ospedaliera Sant'Anna

  collaborator OTHER

• University Hospital Perugia

  collaborator UNKNOWN

• University of L'Aquila

  collaborator OTHER

• Clinica Pediatrica Università di Novara

  collaborator UNKNOWN

• Santobono-Pausilpon Hospital

  collaborator UNKNOWN

• Policlinico G . Martino, Messina Italy

  collaborator UNKNOWN

• IRCCS Azienda Ospedaliero-Universitaria di Bologna

  collaborator OTHER

• University Hospital of Ancona

  collaborator UNKNOWN

• Buzzi Children's Hospital

  lead OTHER

Eligibility

Min Age

5 Years

Max Age

12 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-09-30

Primary Completion

2026-07-31

Completion

2026-10-31

Countries

• Italy

Study Locations