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Effect of Nebulized Magnesium Sulfate on Post-intubation Stress Response in Patients Undergoing Laparoscopic Cholecystectomy

NCT07123714 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 140

Last updated 2025-08-14

No results posted yet for this study

Summary

This randomized controlled double blinded study will be carried out on 140 patients underwent elective fit laparoscopic cholecystectomy at El-Rajhi Assiut University Hospital.

Inclusion criteria:

* 20-50 years old.
* Both sexes.
* American society of anesthesiologists (ASA) physical status I-II.
* Elective fit laparoscopic cholecystectomy

Exclusion criteria:

* Patient refusal.
* Patients with history of hypersensitivity to magnesium sulfate.
* Patients with coronary ischemic disease, atrioventricular block of any degree, known cardiac arrhythmias, heart failure on beta blockers or calcium channel blockers expected difficult intubation (Mallampati 4).
* Body mass index (BMI) \> 40 kg/m2.

An online randomization program (http://www.randomizer.org) will be used to generate a random list and each patients' code will be kept in an opaque sealed envelope. Patients will be randomly allocated with 1:1 allocation ratio into two equal groups in a parallel manner:

* Group A: (N=70) Patients will receive nebulized magnesium sulfate in 5 ml (250 mg) over 15 min.
* Group B: (N=70) Patients received nebulized normal saline in 5 ml over 15 min, ending 5 min before the induction of anesthesia.

A. Preoperative assessment:

All patients will be subjected to the followings:

1. Demographic data collection (age, weight, height, BMI, and ASA).
2. Complete clinical examination.
3. Routine Laboratory investigations:

* Random blood sugar.
* Blood sample withdrawal for cortisol level at baseline 2ml intravenously. The sample will be sent to be centrifugated within 30 minutes and the serum will be separated and stored in -20°C till time of cortisol level by ELIZA technique.

Conditions

  • Sore Throat

Interventions

PROCEDURE

Nebulization of magnesium sulfate

patient will be nebulized with 5 mg magnesium sulfate (5 ml) 15 minutes before induction of anesthesia

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-08-20
Primary Completion
2025-11-01
Completion
2025-11-10

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07123714 on ClinicalTrials.gov