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Neural Contributions to Exercise-Induced Hypoalgesia With Blood Flow Restriction

NCT07122011 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-05-04

No results posted yet for this study

Summary

This experimental study explores the neurophysiological mechanisms associated with pain modulation following a single session of low-intensity resistance exercise combined with BFR in healthy young adults. The study evaluates changes in sensory thresholds before and after the intervention using validated quantitative sensory testing (QST) methods. These include pressure pain thresholds, conditioned pain modulation, thermal thresholds, and temporal summation. The findings may contribute to a better understanding of the role of the nervous system in exercise-induced hypoalgesia, particularly in response to BFR protocols, with implications for future research in pain and rehabilitation.

Conditions

  • Healthy

Interventions

OTHER

Low-Intensity Resistance Training with BFR

Warm-up: Five minutes of light-intensity cycling on a stationary bike. Exercises: 1. Bilateral half squat (0°-90°) 2. Single-leg step-down from a 20 cm step 3. Knee extension (90°-0°) at 30% of one-repetition maximum (1RM) 4. Single-leg shallow squat (0°-45°) Protocol: One set of 30 repetitions (or until volitional fatigue) followed by three sets of 15 repetitions for each exercise. Rest periods: One minute between sets and two minutes between exercises. BFR Application: Pneumatic cuff (The Occlusion Cuff Pro®) placed proximally on the dominant thigh, inflated to 60% of complete arterial occlusion (determined via Doppler ultrasound). The cuff remains inflated during sets and rest periods, and is deflated after completion of each exercise.

Sponsors & Collaborators

  • University of Gran Rosario

    lead OTHER

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-08-04
Primary Completion
2026-02-19
Completion
2026-02-19

Countries

  • Argentina

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07122011 on ClinicalTrials.gov