A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors
NCT07115043 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2026-04-23
Summary
A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors
Conditions
- Melanoma
- Non-small Cell Lung Cancer
- Squamous Cell Carcinoma (Skin)
- Renal Cell Carcinoma
- Merkel Cell Carcinoma
- Triple Negative Breast Cancer
- Head and Neck Squamous Cell Carcinoma
- Gastric Cancer/Gastroesophageal Junction Cancer
- High Grade Serous Ovarian Carcinoma
Interventions
- DRUG
-
Rilvegostomig- PD1-TIGIT bispecific antibody
- DRUG
-
AZD6750
AZD6750- CD8 guided IL-2
Sponsors & Collaborators
- lead INDUSTRY
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-07-29
- Primary Completion
- 2029-10-02
- Completion
- 2029-10-02
- FDA Drug
- Yes
Countries
- United States
- Australia
- Japan
- South Korea
Study Locations
More Related Trials
-
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
NCT04644068 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of the Safety and Efficacy of Atezolizumab Administered in Combination With Bevacizumab and/or Other Treatments in Participants With Solid Tumors
NCT02715531 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7759065 as a Single Agent and in Combination With Atezolizumab in Patients With Locally Advanced or Metastatic Solid Tumors
NCT06488716 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase I/II, Open-label Study to Investigate the Safety, Tolerability, PK, and Preliminary Efficacy of FB849
NCT05761223 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers
NCT05098132 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Safety, Pharmacokinetics, and Antitumor Activity of BGB-B167 Alone and in Combination With Tislelizumab (BGB-A317) in Participants With Advanced Solid Tumors
NCT05494762 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase I Study of Safety, Tolerability, and PK of AZD2811 in Patients With Advanced Solid Tumors.
NCT02579226 ·Status: COMPLETED ·Phase: PHASE1
-
A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study
NCT03768063 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Dose Escalation and Expansion Study of BH3120 Alone or With Pembrolizuamb in Advanced or Metastatic Solid Tumors
NCT06234397 ·Status: RECRUITING ·Phase: PHASE1
-
Safety, Tolerance, PK, and Anti-tumour Activity of AZD1775 Monotherapy in Patients With Advanced Solid Tumours
NCT02482311 ·Status: COMPLETED ·Phase: PHASE1
-
Dose-Escalation and Dose-Expansion Study of BSI-082 Monotherapy and Combined Therapy in Patients With Advanced or Metastatic Solid Tumors
NCT07086768 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
NCT03170960 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IPI-549
NCT02637531 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer
NCT04931654 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
A Phase I Open Label Dose Escalation Study for the Safety and Tolerability of AZD2171 in Solid Tumors in Japan
NCT00503477 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase I Study of AZD1480 in Patients With Advanced Solid Malignancies and Advanced Hepatocellular Carcinoma in the Escalation Phase,Non-Small Cell Lung Cancer(NSCLC) and Non-smokers With Lung Metastasis and Gastric Cancer and Solid Tumour in the Expansion Phase.
NCT01219543 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of LM-350 in Subjects With Advanced Solid Tumours
NCT07112222 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of BG-C477 in Participants With Advanced Solid Tumors
NCT06596473 ·Status: RECRUITING ·Phase: PHASE1
-
Trial to Assess the Safety and Antitumor Activity of GEN1057 in Malignant Solid Tumors
NCT06573294 ·Status: TERMINATED ·Phase: PHASE1
-
Study to Assess Safety, Tolerability and PK of AZD1480 in Patients With Solid Tumours
NCT01112397 ·Status: TERMINATED ·Phase: PHASE1
-
A Dose-escalation Study of RO7567132 as Single Agent and in Combination With Atezolizumab in Participants With Advanced Solid Tumors
NCT06537310 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors
NCT06005493 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Study to Evaluate D-1553 in Subjects With Solid Tumors
NCT04585035 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7566802 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors
NCT06031441 ·Status: RECRUITING ·Phase: PHASE1
-
A Dose-escalation Study in Subjects With Advanced Malignancies
NCT01195311 ·Status: COMPLETED ·Phase: PHASE1