Efficacy and Safety of T-DXd in Patients With HER2-positive and HER2-low Metastatic Breast Cancer: a Real-world Study
NCT07108595 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 142
Last updated 2025-08-07
Summary
Evaluate the efficacy and safety of T-DXd in patients with HER2-positive and HER2-low metastatic breast cancer
Conditions
Interventions
- DRUG
-
T- Dxd
T-DXd based therapy
Sponsors & Collaborators
-
The First Affiliated Hospital with Nanjing Medical University
lead OTHER
Eligibility
- Min Age
- 18 Years
- Max Age
- 85 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2021-01-01
- Primary Completion
- 2024-08-31
- Completion
- 2024-12-31
Countries
- China
Study Locations
More Related Trials
-
Docetaxel 2-weeks Regimen in the Treatment of HER2 Negative Metastatic Breast Cancer
NCT03147963 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer
NCT04494425 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Phase II Study of T-DXd Plus SRT in HER2-positive Breast Cancer Brain Metastases
NCT06088056 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
T-DXd Versus THP for Medium-risk HER2-positive Early Breast Cancer
NCT06548178 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A ReaL World Study of DS-8201
NCT06945224 ·Status: ACTIVE_NOT_RECRUITING
-
A Study of Herceptin (Trastuzumab) in Combination With a Taxane in Participants With HER2-Positive Breast Cancer Who Relapsed After (Neo)Adjuvant Herceptin Treatment
NCT01301729 ·Status: COMPLETED ·Phase: PHASE4
-
Real-world Outcomes of Patients With HER2+ Metastatic Breast Cancer After Treatment With Trastuzumab Deruxtecan
NCT06833268 ·Status: COMPLETED
-
A Study Evaluating the Efficacy and Safety of De Trastuzumab (T-DXd) in Combination with Immunotherapy for the Neoadjuvant Treatment of HR-positive HER2 Low-expressing Chinese Patients with Early-stage Breast Cancer
NCT06733233 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
T-DXd With or Without Neratinib for HER2 Positive Breast Cancer With Brain Metastasis
NCT07152782 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Trastuzumab Plus Taxane Neoadjuvant Therapy for HER2-Positive Breast Ductal Carcinoma In Situ (DCIS) : A Phase II Study
NCT06843681 ·Status: ENROLLING_BY_INVITATION ·Phase: PHASE2
-
Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer
NCT05950945 ·Status: RECRUITING ·Phase: PHASE3
-
Initial CDK 4/6 Inhibitor Plus Endocrine Therapy Versus Initial Chemotherapy in HR Positive, HER2 Negative Unresectable or Metastatic Breast Cancer
NCT06344793 ·Status: COMPLETED
-
Trastuzumab Deruxtecan in Advanced Breast Cancer
NCT07180264 ·Status: RECRUITING
-
Trastuzumab Rezetecan Plus Pertuzumab in the Neoadjuvant Treatment of HER2 Positive BC
NCT07047755 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Study of T-DXd for the Treatment of Solid Tumors Harboring HER2 Activating Mutations
NCT04639219 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Efficacy of Nab-PHP Versus TCbHP in Neoadjuvant Therapy for HER2-positive Early Breast Cancer
NCT07057427 ·Status: RECRUITING ·Phase: PHASE3
-
Real World Patient-Reported Outcomes in Chinese Her2+ EBC Patients Receiving (Neo) Adjuvant Anti-Her2 Based Therapy
NCT06161922 ·Status: RECRUITING
-
Maintenance Therapy in HER2-Positive Unresectable Locally Recurrent or Metastatic Breast Cancer: A Phase II Study
NCT07179939 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Comparison of Nab-PHP and TCbHP Efficacy in Neoadjuvant Therapy for HER2-positive Early Breast Cancer
NCT04547907 ·Status: RECRUITING ·Phase: PHASE3
-
Tucidinostat and Nab-paclitaxel in Advanced HR+/HER2- Breast Cancer
NCT05633914 ·Status: RECRUITING ·Phase: PHASE2
-
Four Cycles Taxane With Trastuzumab and Pertuzumab Neoadjuvant Therapy Among Low Risk HER2 Positive Patients
NCT06722599 ·Status: RECRUITING
-
Observational of Adjuvant Treatment of Breast Cancer With Liposomal Doxorubicin Regimen
NCT05731258 ·Status: RECRUITING
-
A Study to Assess the Efficiency of Trastuzumab Deruxtecan in Russian Breast Cancer Patients
NCT07281001 ·Status: RECRUITING ·Phase: NA
-
Adjuvant Dual Anti-HER2 Therapy in Patients With Small, Node-negative, HER2-positive Breast Cancer
NCT04158856 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Study to Evaluate the Efficacy and Safety of Pertuzumab + Trastuzumab + Docetaxel Versus Placebo + Trastuzumab + Docetaxel in Previously Untreated Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Breast Cancer
NCT02896855 ·Status: COMPLETED ·Phase: PHASE3