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Preoperative Toxicological Screening on Perioperative Anesthetic Management

NCT07100314 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1260

Last updated 2025-08-03

No results posted yet for this study

Summary

Background: Preoperative substance use is a growing concern in patients undergoing metabolic bariatric surgery (MBS), but its impact on short-term outcomes remains debated. This study evaluated the association between preoperative toxicological screening test (TST) results and perioperative outcomes, including anesthesia requirements, postoperative recovery, complications, and one-year weight loss in patients undergoing MBS.

Key Points

1. Preoperative toxicological screening identifies a significant proportion (15.1%) of patients undergoing metabolic bariatric surgery with recent substance use that may not be disclosed through self-reporting.
2. Patients with positive toxicological screening tests require significantly higher anesthesia doses, experience more severe postoperative pain, and have higher rates of complications and readmissions within 30 days.
3. While short-term weight loss outcomes at one year show modest differences between toxicological screening test-positive and negative patients, the perioperative risk profile suggests the need for tailored management strategies for patients with recent substance use.

Conditions

  • Toxicology
  • Bariatric Surgery Analgesia
  • Bariatric Surgery
  • Substance Use

Interventions

DIAGNOSTIC_TEST

Multi-Drug One Step Screen Test Panel (Urine)

Tested positive

DIAGNOSTIC_TEST

Multi-Drug One Step Screen Test Panel (Urine)

tested negative

Sponsors & Collaborators

  • General Committee of Teaching Hospitals and Institutes, Egypt

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-12-01
Primary Completion
2024-05-01
Completion
2024-06-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07100314 on ClinicalTrials.gov