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Effective Interventions to Overcome Severe Gag Reflex

NCT07099131 · Status: NOT_YET_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2025-08-01

No results posted yet for this study

Summary

The purpose of this study is to evaluate the use of various techniques in alleviating gag reflex following gag reflex stimulation.

Primary aim: To compare if there is any reduction in gag reflex from each of the following interventions

* Acupuncture (CV-24)
* Tape
* Anesthetic spray Secondary aim: to compare the degree of gag reduction

Conditions

  • Gagging

Interventions

DRUG

Anesthetic spray

will be applied to back of the throat for 10 seconds; their chin will also be concealed from the GSI examiner using a small cup and masking tape.

DEVICE

Acupuncture

A 6C file (endodontic instrumentation file) will be placed on the patient's mentolabial fold (CV24). This file will be concealed by a small paper cup; A clean alcohol wipe will be used to clean the mentolabial area prior to placing the "acupuncture needle" (6 C-File).

GENETIC

Masking Tape

A piece of commercially available masking tape will be adhered to the patient's mentolabial fold and concealed by the small paper cup

Sponsors & Collaborators

  • Tufts University

    lead OTHER

Principal Investigators

  • Devon Ptak · Tufts University School of Dental Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-12-07
Primary Completion
2027-12-07
Completion
2028-12-07
FDA Drug
Yes
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07099131 on ClinicalTrials.gov