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Stem Cell Recruitment in Exercised Skeletal Muscles of Older Women by Phytosteroid Rg1

NCT07093190 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 11

Last updated 2025-07-30

No results posted yet for this study

Summary

The goal of this interventional study is to observe the effects of bone marrow stem cell behavior in skeletal muscle of women between 60 to 75 years old after a single moderate resistance exercise session. Plant sterol Rg1, a compound known to enhance stem cell infiltration following exercise in young men will be tested against a placebo in a double blinded crossover design.

The main questions to be answered are:

* Does Rg1 supplementation alter serum sex hormone levels in recovery from exercise?
* Does Rg1 supplementation influence bone marrow stem cell differentiation in skeletal muscles of older women?

Participants will:

* Pre-test body composition, maximal leg strength, blood and muscle tissue.
* One hour after taking the supplement, participants will perform 4 sets of 10 repetitions of 70% of maximal strength (1RM) leg press and have two thigh muscle biopsies (0 and 24 h after exercise).
* Repeat the protocol one month later on the alternative supplement. Researchers will understand whether Rg1 improves recovery response to resistance exercise in post-menopausal women.

Conditions

  • Exercise Training
  • Post-menopausal Women
  • Bone Marrow Stem Cells
  • Skeletal Muscle Recovery

Interventions

DIETARY_SUPPLEMENT

exercise following Rg1 consumption

The effect of Rg1 on exercised skeletal muscle in older women

DIETARY_SUPPLEMENT

Placebo

Resistance exercise performed 1 hour following placebo consumption

Sponsors & Collaborators

  • University of Taipei

    lead OTHER

Principal Investigators

  • Chia-hua Kuo, PhD · University of Taipei

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
60 Years
Max Age
70 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-18
Primary Completion
2022-12-02
Completion
2025-07-01

Countries

  • Taiwan

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07093190 on ClinicalTrials.gov