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Anastomotic Leakage in Colorectal Cancer Surgery in Syria

NCT07092631 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 119

Last updated 2026-01-06

No results posted yet for this study

Summary

Anastomotic leakage is a serious complication of colorectal cancer surgery, particularly in resource-limited and conflict-affected settings. This retrospective cohort study conducted at Damascus Hospital, Syria, evaluated patient and procedure related risk factors for anastomotic leakage following elective sigmoid colon and rectal resections. An initial cohort (January 2016-March 2024) identified modifiable risk factors that informed updates to institutional preoperative and perioperative guidelines. A follow-up cohort (April 2024-October 2025) was subsequently analyzed to assess outcomes after guideline implementation. The study demonstrates that targeted optimization, especially correction of hypoalbuminemia and improved perioperative management was associated with reduced anastomotic leakage and postoperative mortality, highlighting the value of context-specific, evidence-based guideline changes in low-resource surgical settings.

Conditions

  • Anastomotic Leakage in Colon Surgery
  • Anastomotic Leak Rectum
  • Anastomotic Leak Large Intestine

Sponsors & Collaborators

  • Syrian Private University

    collaborator OTHER

  • Damascus Hospital

    collaborator OTHER

  • Elie Bitar

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-01-04
Primary Completion
2025-10-08
Completion
2025-10-20

Countries

  • Syria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07092631 on ClinicalTrials.gov