A Study to Evaluate the Efficacy and Safety of ICP-248 in Subjects With Relapsed or Refractory Mantle Cell Lymphoma (APEX-06)
NCT07082686 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 75
Last updated 2026-04-27
Summary
This is a single-arm, multi-center, open-label, phase 2 study to evaluate the efficacy and safety of ICP-248 in subjects with relapsed or refractory mantle cell lymphoma.
Conditions
- Relapsed or Refractory Mantle Cell Lymphoma (MCL)
Interventions
- DRUG
-
ICP-248
Eligible patients will receive ICP-248 orally as per the protocol
Sponsors & Collaborators
-
Beijing InnoCare Pharma Tech Co., Ltd.
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-08-21
- Primary Completion
- 2027-12-31
- Completion
- 2028-07-31
Countries
- China
Study Locations
More Related Trials
-
Ibrutinib Combined With Rituximab for Treatment of Relapsed Refractory MYD88 and CD79A/B (or CD79B Alone) DLBCL Who Have Received at Least Two Prior Therapies
NCT04994626 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of LP002 for the Treatment of Patients With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma
NCT04600947 ·Status: UNKNOWN ·Phase: PHASE2
-
A Phase I/II Study of LM-101 Injection in Patients With Advanced Malignant Tumors
NCT05615974 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
The Study of ICP-248 in Patients With Mature B-cell Malignancies
NCT05728658 ·Status: RECRUITING ·Phase: PHASE1
-
Phase II Clinical Study of PLM60 for the Treatment of Cutaneous T Cell Lymphomas
NCT02597153 ·Status: TERMINATED ·Phase: PHASE2
-
To Evaluate the Safety and Efficacy of TQB2618 Injection Combined With Penpulimab in the Treatment of Patients With Relapsed and Refractory Lymphoma
NCT05400876 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Pembrolizumab in Combination With R-ICE Chemotherapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma
NCT05221645 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Imvotamab Monotherapy and in Combination in Subjects With Relapsed/Refractory Non-Hodgkin Lymphoma
NCT04082936 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Study of Standard and Individualized Treatment Model for Relapse and Refractory Lymphatic System Malignant Tumors
NCT02929615 ·Status: UNKNOWN ·Phase: PHASE4
-
A Study of C-CAR039 Treatment in Subjects With r/r NHL Subjects Non-Hodgkin's Lymphoma
NCT04693676 ·Status: UNKNOWN ·Phase: PHASE1
-
A Single-arm, Multicenter, Prospective Clinical Study of Mitoxantrone Liposome Combined With Chidamide and Azacitidine in the Treatment of Relapsed and Refractory Peripheral T-cell Lymphoma
NCT05495100 ·Status: UNKNOWN ·Phase: PHASE2
-
Phase Ⅰ Clinical Study of Anti-CD52 Monoclonal Antibody in NHL and T-PLL
NCT05557903 ·Status: UNKNOWN ·Phase: PHASE1
-
Efficacy and Safety of MB-CART2019.1 vs. SoC in Lymphoma Patients
NCT04844866 ·Status: RECRUITING ·Phase: PHASE2
-
Lenalidomide Based Immunotherapy in the Treatment of DLBCL
NCT03715296 ·Status: UNKNOWN
-
Ibrutinib Combined With R-CHOP/R-DHAP in Newly Diagnosed Mantle Cell Lymphoma Patients Who Aged ≤65 Years
NCT05429918 ·Status: UNKNOWN
-
A Study of INCB050465 in Relapsed or Refractory Mantle Cell Lymphoma Previously Treated With or Without a Bruton's Tyrosine Kinase (BTK) Inhibitor
NCT03235544 ·Status: COMPLETED ·Phase: PHASE2
-
Ibrutinib After Intensive Induction in Treating Patients With Previously Untreated Mantle Cell Lymphoma
NCT02242097 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
An Early Clinical Study Evaluating the Safety and Efficacy of AcNK-Sup003 Cell Injection in the Treatment of Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma
NCT06693973 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Glofitamab in Chinese Patients With R/R DLBCL
NCT06481826 ·Status: RECRUITING
-
A Trial to Compare Ibrutinib Versus Lenalidomide in Combination With MRE-chemotherapy for Adult Patients With Recurrent/Refractory Primary Central Nervous System Lymphoma (PCNSL)
NCT04129710 ·Status: RECRUITING ·Phase: PHASE2
-
Relmacabtagene Autoleucel as First-Line Therapy for High-Risk Large B-Cell Lymphoma
NCT05590221 ·Status: RECRUITING ·Phase: PHASE2
-
A Study of Ibrutinib With Rituximab in Relapsed or Refractory Mantle Cell Lymphoma
NCT05564052 ·Status: COMPLETED ·Phase: PHASE2
-
A Study Of PF-05082566 As A Single Agent And In Combination With Rituximab
NCT01307267 ·Status: COMPLETED ·Phase: PHASE1
-
Study of MK 2206 in Patients With Relapsed or Refractory Diffuse Large B Cell Lymphoma
NCT01466868 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Mitoxantrone Hydrochloride Liposome Infusion
NCT02856685 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2