A Phase I, Open-label, Multicenter Study to Evaluate the Safety, Tolerability, Cellular Kinetics, Immunogenicity, Pharmacodynamics, and Preliminary Efficacy of AZD0120 in Participants With Multiple Myeloma (DURGA-2)
NCT07073547 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2026-04-28
Summary
This is an interventional, modular, open-label, multicenter study to primarily evaluate the safety and tolerability of AZD0120 in adult participants with multiple myeloma (MM).
Conditions
Interventions
- BIOLOGICAL
-
AZD0120
AZD0120 is a BCMA/CD19 dual CAR T cell product under investigation for early-line treatment in subjects with multiple myeloma
Sponsors & Collaborators
- lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-07-31
- Primary Completion
- 2028-05-26
- Completion
- 2028-05-26
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
MEDI2228 in Subjects With Relapsed/Refractory Multiple Myeloma
NCT03489525 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of AT7519M Alone and AT7519M Plus Bortezomib in Patients With Previously Treated Multiple Myeloma
NCT01183949 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of Oral Ixazomib Citrate (MLN9708) Maintenance Therapy in Participants With Multiple Myeloma Following Autologous Stem Cell Transplant
NCT02181413 ·Status: COMPLETED ·Phase: PHASE3
-
Lenalidomide + Azacitidine for Adaptive Immunotherapy -> Auto SCT in Multiple Myeloma
NCT01050790 ·Status: COMPLETED ·Phase: NA
-
AZD6244 (Selumetinib) in Treating Patients With Multiple Myeloma
NCT01085214 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy and Donor Stem Cell Transplant Followed by Ixazomib Citrate Maintenance Therapy in Treating Patients With Relapsed High-Risk Multiple Myeloma
NCT02504359 ·Status: COMPLETED ·Phase: PHASE1
-
2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy
NCT03004287 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study to Assess A Change in Disease Activity and Adverse Events of Intravenous Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Adult Participants With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
NCT07095452 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Bortezomib, Rituximab, and Dexamethasone With or Without Temsirolimus in Treating Patients With Untreated or Relapsed Waldenstrom Macroglobulinemia or Relapsed or Refractory Mantle Cell or Follicular Lymphoma
NCT01381692 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
2015-09: a Phase II Randomized, Open-label Study of Anti-signaling Lymphocytic Activation Molecule Monoclonal Antibody During Maintenance Therapy
NCT03000634 ·Status: WITHDRAWN ·Phase: PHASE2
-
2017-03: A Single-Arm, Open-label Study of Anti-Signaling Lymphocytic Activation Molecule F7 (Anti-SLAMF7) Monoclonal Antibody (mAb) Therapy After Autologous Stem Cell Transplant in Patients With Multiple Myeloma
NCT03168100 ·Status: WITHDRAWN ·Phase: PHASE2
-
A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma
NCT04108195 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
S1211 Bortezomib, Dexamethasone, and Lenalidomide With or Without Elotuzumab in Treating Patients With Newly Diagnosed High-Risk Multiple Myeloma
NCT01668719 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study to Investigate the Clinical Benefit of Isatuximab in Combination With Bortezomib, Lenalidomide and Dexamethasone in Adults With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
NCT03319667 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Autologous Stem Cell Transplant Followed By Maintenance Therapy in Treating Elderly Patients With Multiple Myeloma
NCT01849783 ·Status: COMPLETED ·Phase: PHASE2
-
International Treatment-extension Study in Adult Participants With Multiple Myeloma and Who Have Derived Clinical Benefit From Isatuximab
NCT05669989 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Alternating Ixazomib Citrate and Lenalidomide as Maintenance Therapy After Stem Cell Transplant in Treating Patients With Multiple Myeloma
NCT02619682 ·Status: COMPLETED ·Phase: PHASE2
-
Bortezomib With Melphalan and Prednisone for Multiple Myeloma
NCT00734149 ·Status: COMPLETED ·Phase: PHASE2
-
Ixazomib as a Replacement for Carfilzomib and Bortezomib for Multiple Myeloma Patients
NCT02206425 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Randomized Trial of Lenalidomide, Bortezomib, Dexamethasone vs High-Dose Treatment With SCT in MM Patients up to Age 65
NCT01208662 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Daratumumab, Azacitidine, and Dexamethasone for Treatment of Patients With Recurrent or Refractory Multiple Myeloma Previously Treated With Daratumumab
NCT04407442 ·Status: TERMINATED ·Phase: PHASE2
-
Ph 1b Study to Evaluate GSK2110183 in Combination With Bortezomib and Dexamethasone in Subjects With Multiple Myeloma
NCT01428492 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Oral Ixazomib Maintenance Therapy in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Not Treated With Stem Cell Transplantation (SCT)
NCT02312258 ·Status: COMPLETED ·Phase: PHASE3
-
²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myeloma
NCT04579523 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
Low-Dose Azacitidine, Lenalidomide, and Low-Dose Dexamethasone in Relapsed or Refractory Multiple Myeloma
NCT01155583 ·Status: COMPLETED ·Phase: PHASE1/PHASE2