A Phase II Study of SHR-8068 Injection in Combination With Anti-tumor Therapies in Colorectal Cancer
NCT07071714 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 200
Last updated 2026-03-18
Summary
The study is being conducted to evaluate the safety, tolerability and efficacy of SHR-8068 injection in combination with anti-tumor therapies in subjects with colorectal cancer.
Conditions
Interventions
- DRUG
-
SHR-8068 Injection
SHR-8068 injection.
- DRUG
-
Adebrelimab Injection
Adebrelimab injection.
- DRUG
-
Bevacizumab Injection
Bevacizumab injection.
Sponsors & Collaborators
-
Suzhou Suncadia Biopharmaceuticals Co., Ltd.
lead INDUSTRY
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-07-22
- Primary Completion
- 2031-10-31
- Completion
- 2031-10-31
Countries
- China
Study Locations
More Related Trials
-
A Trial of SHR-1210 in Combination With AIN457 in Patients With MSS CRC(SHR-1210-AIN457)
NCT04298320 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)
NCT06149481 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Recombinant Anti-tumor and Anti-virus Protein for Injection Plus Xeloda in Treatment of Metastatic Colorectal Cancer
NCT02068131 ·Status: UNKNOWN ·Phase: PHASE2
-
Safety and Pharmacokinetics of Recombinant Anti-EGFr Antibody in Patients With Metastatic Colorectal Cancer
NCT03017807 ·Status: COMPLETED ·Phase: PHASE1
-
Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal Cancer
NCT00975897 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
SBRT Sequential CapeOX Regimen Combined With Bevacizumab and Sintilimab in First-line Treatment of mCRC
NCT05438108 ·Status: UNKNOWN ·Phase: PHASE2
-
Phase I Study of Biweekly SIRB Regimen for Metastatic Colorectal Cancer
NCT03380689 ·Status: WITHDRAWN ·Phase: PHASE1
-
A Clinical Study of T3011 in Combination With Regorafenib in Patients With Advanced Colorectal Cancer
NCT06200363 ·Status: RECRUITING ·Phase: PHASE1
-
Modulation Of The Tumour Microenvironment Using Either Vascular Disrupting Agents or STAT3 Inhibition in Order to Synergise With PD1 Inhibition in Microsatellite Stable, Refractory Colorectal Cancer
NCT03647839 ·Status: COMPLETED ·Phase: PHASE2
-
An Investigational Immunotherapy Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Colorectal Cancer That Has Spread
NCT03414983 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
ARTEMIS-102: HS-20093 Combinations in Patients with Advanced Metastatic Colorectal Cancer
NCT06825624 ·Status: RECRUITING ·Phase: PHASE1
-
Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors
NCT06040541 ·Status: RECRUITING ·Phase: PHASE1
-
Surufatinib With or Wothout Immunotherapy for Advanced Colorectal Cancer in Later Line
NCT05372198 ·Status: UNKNOWN ·Phase: PHASE2
-
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
NCT06428409 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Anlotinib Combined With mXELIRI as Second-line Treatment of Advanced Colorectal Cancer
NCT05035914 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Recombinant Anti-tumor and Anti-virus Protein for Injection in Treatment of Metastatic Colorectal Cancer
NCT01386242 ·Status: COMPLETED ·Phase: PHASE2
-
NKTR-102 Versus Irinotecan in Patients With Second-Line, Irinotecan-Naïve, KRAS Mutant, Colorectal Cancer
NCT00856375 ·Status: COMPLETED ·Phase: PHASE2
-
QL1706 Injection Plus Bevacizumab and XELOX vs Placebo Plus Bevacizumab and XELOX as First-Line Treatment of Unresectable Metastatic Colorectal Cancer
NCT07025239 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
Phase 2 Study of SR-8541A in Combination With Botensilimab and Balstilimab in Subjects With Refractory Metastatic Microsatellite Stable Colorectal Cancer (MSS-CRC)
NCT06589440 ·Status: RECRUITING ·Phase: PHASE2
-
Study of MK-8353 in Combination With Pembrolizumab (MK-3475) in Participants With Advanced Malignancies (MK-8353-013)
NCT02972034 ·Status: TERMINATED ·Phase: PHASE1
-
Evaluation of Revumenib in Participants With Colorectal Cancer and Other Solid Tumors
NCT05731947 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of Nivolumab-relatlimab Fixed-dose Combination Versus Regorafenib or TAS-102 in Participants With Later-lines of Metastatic Colorectal Cancer
NCT05328908 ·Status: TERMINATED ·Phase: PHASE3
-
A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Advanced Gastrointestinal Cancer
NCT02024607 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
NCT04486378 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Regorafenib and Nivolumab in Mismatch Repair (MMR) Refractory Colorectal Cancer
NCT03712943 ·Status: COMPLETED ·Phase: PHASE1