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Bruxism and Temporomandibular Joint Vibrational Analysis Study

NCT07070141 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 195

Last updated 2025-07-17

No results posted yet for this study

Summary

Background and Rationale

Bruxism is a repetitive jaw-muscle activity involving clenching or grinding of the teeth. Although its pathophysiology remains unclear, it is hypothesized that bruxism may contribute to biomechanical alterations in the temporomandibular joint (TMJ). Joint Vibration Analysis (JVA) is a non-invasive method capable of detecting vibrational patterns associated with TMJ function. This study protocol aims to assess the potential association between bruxism and TMJ vibrational characteristics in adults.

Objectives

The primary objective is to determine whether there is a difference in TMJ vibrational parameters between individuals with clinically diagnosed bruxism and individuals without signs or symptoms of bruxism. The secondary objective is to explore the relationship between bruxism severity and specific vibrational parameters measured by JVA.

Study Design

This is a retrospective observational study of patient records collected between January 2020 and May 2025 at the Istanbul Atlas University TMD Clinic.

Study Population

* Inclusion Criteria:
* Adults aged 18-45 years
* Documented bruxism evaluation
* Complete Joint Vibration Analysis (JVA) recordings
* Exclusion Criteria:
* History of orthodontic treatment within the past year
* TMJ surgery or major facial trauma
* Neurological or systemic inflammatory conditions
* Pregnancy at time of evaluation
* Use of medications affecting neuromuscular activity

Sample Size

Approximately 195 patient records meeting eligibility criteria will be analyzed. The bruxism group is expected to include \~175 participants, and the control group \~20 participants.

Methodology

Clinical data include patient-reported bruxism history, maximum mouth opening measurements, and TMJ clinical assessments. JVA recordings will be used to obtain vibrational parameters such as peak frequency, median frequency, amplitude, and total vibrational energy. Standardized protocols for JVA will be applied to all included patients.

Statistical Analysis

Data normality will be assessed. For normally distributed variables, independent t-tests will be used to compare groups; for non-normally distributed variables, Mann-Whitney U tests will be applied. Correlation between bruxism severity and vibrational parameters will be evaluated using Spearman's rank correlation. Multiple linear regression may be used to analyze the predictive value of bruxism indicators.

Ethics

The study protocol has been approved by the Istanbul Atlas University Clinical Research Ethics Committee (Approval No: E-22686390-050.99-66516). Informed consent for use of anonymized data was obtained at the time of clinical examination.

Conditions

  • Bruxism
  • Temporomandibular Disorder (TMD)

Interventions

DIAGNOSTIC_TEST

Diagnostic work up

None intervention

Sponsors & Collaborators

  • Atlas University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-01
Primary Completion
2025-02-01
Completion
2025-06-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07070141 on ClinicalTrials.gov