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Repurposing Itraconazole as an Adjuvant Therapy in Treatment of Patients With Acute Myeloid Leukemia: Is it a Hopeful Avenue for Enhancing Treatment Options?

NCT07069933 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2025-07-17

No results posted yet for this study

Summary

A prospective, randomized, controlled, parallel clinical trial will be conducted at Clinical Oncology and Nuclear Medicine Center at Mansoura University Hospital to assess the efficacy of Itraconazole as an adjuvant therapy in treatment of patients with acute myeloid Leukemia.

Conditions

Interventions

DRUG

Standard care +itraconazole 200mg

Is an antifungal used to treat a variety of fungal infections. It belongs to a class of drugs known as azole antifungals.

DRUG

Chemotherapy

Standard Care (in control arm)

Sponsors & Collaborators

  • Mansoura University

    lead OTHER

Principal Investigators

  • Mohamed el-Husseiny shams · Professor Department of Clinical pharmacy and Pharmacy practice, Faculty of Pharmacy, Mansoura University

  • Moetaza Mahmoud Hassab Soliman · Associate professor of Clinical Pharmacy, Clinical Pharmacy and Pharmacy Practice Department, Faculty of Pharmacy, Mansoura University

  • Noha Osama Mansour Mansour · Lecturer of Clinical Pharmacy, Clinical Pharmacy and Pharmacy Practice Department, Faculty of Pharmacy, Mansoura University

  • Sara Mohamed Ali Atwa · Lecturer of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Mansoura University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-07-31
Primary Completion
2025-07-31
Completion
2025-12-31

Countries

  • Egypt

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07069933 on ClinicalTrials.gov