Accelerated Treatment for Co-occurring Insomnia, Nightmares, and PTSD

Summary

This study is a two-arm individually randomized group treatment clinical trial evaluating behavioral therapies for insomnia, nightmares, and PTSD. The study will compare cognitive-behavioral therapy for insomnia and nightmares to sleep hygiene (Control), both integrated with Written Exposure Therapy for PTSD and delivered in an accelerated (i.e., 5-day) group treatment format, preceded and followed by individual treatment sessions. 160 participants will be randomized into one of two study conditions.

Conditions

• Insomnia
• PTSD - Post Traumatic Stress Disorder
• Nightmares

Interventions

BEHAVIORAL

Cognitive-Behavioral Therapy for Insomnia (CBTi)

CBTi focuses on stimulus control, eliminating maladaptive coping habits, reducing arousal, and challenging maladaptive thoughts about sleep in an effort to reduce time to fall asleep and time awake during the night.

BEHAVIORAL

Cognitive Behavioral Therapy for Nightmares (CBTn)

CBTn involves writing about a distressing or frequent nightmare, rewriting the narrative of the nightmare to target trauma-related themes, and reading the rescripted nightmare narrative.

BEHAVIORAL

Written Exposure Therapy (WET)

WET is a trauma-focused intervention in which individuals write about their worst traumatic experience following scripted instruction from the therapist.

BEHAVIORAL

Sleep Hygiene

Involves reviewing sleep diary data, sleep education, and reviewing and discussing sleep hygiene practices.

Sponsors & Collaborators

• The University of Texas Health Science Center at San Antonio

  collaborator OTHER

• University of Arizona

  collaborator OTHER

• NDRI-USA, Inc.

  collaborator OTHER

• Palo Alto Veterans Institute for Research

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-12-02

Primary Completion

2028-12-01

Completion

2028-12-01

Countries

• United States