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SLE Severity Linked to Vitamin D Via Treg Cells in Pediatric Patients

NCT07069348 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 32

Last updated 2025-07-18

No results posted yet for this study

Summary

SLE has been characterized by dysfunctional or decreased numbers of Treg cells because one of it function is to prevent autoimmunity. Vitamin D has already known to increase the number and function of Treg by enhancing their differentiation and expansion. This study aims to investigate the relationship between SLE severity in pediatric patients and vitamin D levels through modulation of Treg cells. This is a cross-sectional study of all children aged 7-18 years old who sought care for SLE at Dr. Saiful Anwar Hospital Malang between March 2024 until December 2024. 25(OH)D level was obtained by ELISA, Treg cell percentage was obtained by flow cytometry, and patient severity was measured by SLEDAI score.

Conditions

Interventions

OTHER

No intervention

There is no treatment or intervention administered to the patients

Sponsors & Collaborators

  • Wisnu Barlianto

    lead OTHER

Principal Investigators

  • Wisnu Barlianto, Prof. · Faculty of Medicine Universitas Brawijaya

Eligibility

Min Age
7 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-03-03
Primary Completion
2024-12-03
Completion
2024-12-03

Countries

  • Indonesia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07069348 on ClinicalTrials.gov