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Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease

NCT07067229 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-09-25

No results posted yet for this study

Summary

Motor neuron disease (MND) is a progressive neurological disorder involving degeneration of motor neurons, leading to muscle weakness, speech and swallowing difficulties, and respiratory failure. This study aims to develop a novel treatment approach combining personalized repetitive transcranial magnetic stimulation (rTMS) with mixed reality (MR) exercise-based games (exergames) to slow disease progression and improve quality of life. In this randomised controlled trial study will compare three groups: (1) rTMS with MR exercise (personalized intervention), (2) rTMS with MR exercise (standard intervention), and (3) sham rTMS with MR exercise. Outcomes will be assessed at baseline, 3 months, and 6 months post intervention. The long-term goal is to implement this approach in clinical settings to enhance care for people with MND.

Conditions

  • ALS (Amyotrophic Lateral Sclerosis)

Interventions

DEVICE

Personalized rTMS

Personalized repetitive transcranial magnetic stimulation (TMS) together with mixed-reality (MR) exercise

DEVICE

Standard rTMS

Standard repetitive transcranial magnetic stimulation (TMS) together with mixed-reality (MR) exercise

DEVICE

Sham rTMS

Sham rTMS together with mixed-reality (MR) exercise

Sponsors & Collaborators

  • King Chulalongkorn Memorial Hospital

    collaborator OTHER

  • Chulalongkorn University

    lead OTHER

Principal Investigators

  • Jakkrit Amornvit, MD · Chulalongkorn University

  • Phunsuk Kantha, PT.,PhD · Mahidol University

  • Kulvara Lapanan, PT · Chulalongkorn University and Neuroscience Resesarch Australia

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-01
Primary Completion
2027-08-30
Completion
2027-12-30

Countries

  • Thailand

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07067229 on ClinicalTrials.gov