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The Effect of Asymmetrical vs. Symmetrical High Flow Nasal Cannula on the Work of Breathing

NCT07066566 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2025-07-18

No results posted yet for this study

Summary

The goal of this study randomized single-center crossover study is to evaluate the impact of asymmetrical versus symmetrical nasal high flow (NHF) therapy on work of breathing (WOB). The main question it aims to answer are:

1\. Does the asymmetrical NHF interface improve the work of breathing compared to the symmetrical NHF interface? Researchers will compare the symmetrical NHF interface to the symmetrical NHF interface to see if the the asymmetrical interface has a greater impact on the work of breathing.

Participants will :

1. receive NHF via both interfaces (FiO₂ 0.21, 50 L/min) for 15 minutes, in random order, with esophageal pressure monitoring and bioelectrical impedance analysis performed.
2. baseline characteristics will me monitored throughout the interventions
3. Esophageal pressure and minute ventilation will be monitored.

Conditions

  • Respiratory Disease (Clinically Stable Individuals - Patients Recovered From Respiratory Disease)

Interventions

DEVICE

Asymmetric nasal cannula - DUET

DUET asymmetric nasal high flow interface that fits best to patients' nostrils (size: one nostril of the patient should be fully occluded) Patients will be crossed - over between the 2 interventions

DEVICE

Conventional nasal high flow cannula

Well - established conventional nasal high flow cannula (size: medium) Patients will be cross - over between the 2 interventions

Sponsors & Collaborators

  • Larissa University Hospital

    lead OTHER

Principal Investigators

  • Demosthenes Makris · Professor of Intensive Care Unit, University Hospital of Larissa

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-04-09
Primary Completion
2025-09-01
Completion
2025-09-01

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07066566 on ClinicalTrials.gov