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A Clinical Evaluation of Marula-Derived Ceramide Cream on Skin Barrier Function Enhancement

NCT07066150 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2025-07-15

No results posted yet for this study

Summary

Previously, the investigators have demonstrated in vitro the excellent efficacy of marula oil-derived ceramide NPs in enhancing skin barrier function. The investigators's findings show that marula oil-derived ceramide NPs not only significantly reduces levels of inflammatory cytokines but also promotes the expression of key proteins in skin barrier integrity. These results suggest that marula oil-derived ceramide NPs may offer a more effective therapeutic option for skin barrier-disrupted diseases. Therefore, the investigators aim to further investigate the repair function of marula oil-derived ceramide NPs on the human epidermal barrier through a clinical trial.

Conditions

  • Atopic Dermatitis (AD)
  • Psoriasis
  • Acne Vulgaris
  • Contact Dermatitis
  • Photodamaged Skin
  • Ichthyosis
  • Xerosis Cutis

Interventions

OTHER

Apply a cream containing 0.05% marula oil-derived ceramide NPs

The participants were requested to apply a cream containing 0.05% marula oil-derived ceramide NPs on their faces twice daily for 28 consecutive days.

Sponsors & Collaborators

  • SGS S.A.

    collaborator INDUSTRY

  • Shanghai Chicmax Cosmetic Co., Ltd.

    lead INDUSTRY

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-06
Primary Completion
2025-03-06
Completion
2025-04-02

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07066150 on ClinicalTrials.gov