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Multi-centred Clinico-genetic Study of Actinic Prurigo in Thailand

NCT07055009 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 47

Last updated 2026-05-12

No results posted yet for this study

Summary

This research project investigates the clinical and genetic associations of Actinic Prurigo (AP) in the Thai population. As a rare chronic photodermatosis, AP has been observed to occur more frequently in individuals with certain genetic predispositions, particularly specific Human Leukocyte Antigen (HLA) types. Previous studies have suggested variations in clinical presentation and HLA allele distributions between Asian and Western populations.

The primary aim is to explore the relationship between clinical manifestations of AP and genetic profiles, including HLA typing, among Thai individuals. Additionally, the study seeks to examine whether different HLA types are associated with varying responses to treatment.

The study design is a cross-sectional comparative study, involving both AP patients and age-matched healthy controls. Given the rarity of the condition, patient recruitment will be conducted across four collaborating institutions:

King Chulalongkorn Memorial Hospital Siriraj Hospital Institute of Dermatology

Conditions

  • Actinic Prurigo

Interventions

OTHER

RNA extraction

Nanostring technology, Seattle

OTHER

Full Skin examination

Skin and mucosa examination

DIAGNOSTIC_TEST

Targeted long-read HLA sequencing

Genetic study

Sponsors & Collaborators

  • Health Systems Research Institute,Thailand

    collaborator OTHER_GOV

  • Chulalongkorn University

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-03-30
Primary Completion
2026-05-31
Completion
2026-12-31

Countries

  • Thailand

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07055009 on ClinicalTrials.gov