A Phase II Clinical Study of AK104/AK112 in Combination With TT-00420 Tablet for Advanced HCC.
NCT07052253 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 100
Last updated 2026-03-16
Summary
An Open-label, Multicenter, Phase II Clinical Study of AK104/AK112 in Combination with TT-00420 Tablet in Patients with Advanced Hepatocellular Carcinoma(HCC).
Conditions
- Hepatocellular Carcinoma (HCC)
Interventions
- DRUG
-
TT-00420 (tinengotinib)
oral
- DRUG
-
AK104
intravenous
- DRUG
-
AK112
intravenous
Sponsors & Collaborators
-
TransThera Sciences (Nanjing), Inc.
collaborator INDUSTRY - lead INDUSTRY
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-07-18
- Primary Completion
- 2027-05-10
- Completion
- 2027-12-31
Countries
- China
Study Locations
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