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Pediatric Non-Steroidal Anti-Inflammatory Drugs (NSAID) Allergy Study

NCT07034066 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 257

Last updated 2025-06-24

No results posted yet for this study

Summary

Non-steroidal anti-inflammatory drugs (NSAIDs) are some of the most commonly used medications to treat pain and inflammation. Many are available over the counter and are frequently used in children to reduce fever and relieve pain. Hypersensitivity (HS) to NSAIDs affects an estimated 0.6% to 5.7% of the general population. These reactions can be caused by immune or non-immune mechanisms. In most cases, they fall into two categories: reactions to a single NSAID or to several different NSAIDs.

Currently, the main way to diagnose NSAID hypersensitivity is through a drug provocation test (DPT)-this involves giving the patient the suspected drug under medical supervision to check for a reaction. It's considered the most reliable method. However, diagnosing these reactions in children can be challenging. Symptoms can vary widely, and there are few accurate alternative tests available to replace the DPT.

This study looks for easier ways-like symptoms or lab tests-to diagnose NSAID reactions, so fewer patients need to go through multiple DPT.

Conditions

  • NSAID
  • Biomarkers
  • Phenotyping
  • Children

Sponsors & Collaborators

  • Hospital Sant Joan de Deu

    collaborator OTHER

  • Fundació Sant Joan de Déu

    lead OTHER

Eligibility

Min Age
1 Month
Max Age
17 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-03-15
Primary Completion
2024-12-30
Completion
2025-05-01

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07034066 on ClinicalTrials.gov