Effects of Trans-spinal Magnetic Stimulation on Cortical Excitability in Healthy Individuals

Summary

This study investigates the immediate effects of different parameters (frequency and intensity) of trans-spinal magnetic stimulation (TsMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEP), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.

Conditions

• Healthy Individuals

Interventions

DEVICE

Trans-spinal magnetic stimulation (90% MT + 1 Hz)

Low frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICE

Trans-spinal magnetic stimulation (100% MT + 1 Hz)

Low frequency stimulation (1 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICE

Trans-spinal magnetic stimulation (110% MT + 1 Hz)

Low frequency stimulation (1 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICE

Trans-spinal magnetic stimulation (90% + 10 Hz)

High frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICE

Trans-spinal magnetic stimulation (100% MT + 10 Hz)

High frequency stimulation (10 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICE

Trans-spinal magnetic stimulation (110% MT + 10 Hz)

High frequency stimulation (10 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICE

Trans-spinal magnetic stimulation (90% MT + 25 Hz)

High frequency stimulation (25 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICE

Trans-spinal magnetic stimulation (100% MT + 25 Hz)

High frequency stimulation (25 Hz) at 100% of resting motor threshold intensity, delivering a total of 2400 pulses.

DEVICE

Trans-spinal magnetic stimulation (110% MT + 25 Hz)

High frequency stimulation (25 Hz) at 110% of resting motor threshold intensity, delivering a total of 2400 pulses.

Sponsors & Collaborators

• Universidade Federal de Pernambuco

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

40 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-10-01

Primary Completion

2025-09-30

Completion

2025-10-30

Countries

• Brazil

Study Locations