Tislelizumab Combined With Chemotherapy for the Perioperative Treatment of Esophageal Squamous Carcinoma
NCT07019181 · Status: NOT_YET_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 26
Last updated 2025-06-13
Summary
Evaluating the rate of pathologic complete remission in patients with squamous esophageal cancer treated perioperatively with tislelizumab in combination with chemotherapy
Conditions
- Esophagus Cancer
Interventions
- DRUG
-
Tislelizumab
Tislelizumab, 200mg, intravenously over 30 - 60 minutes, day 1 of every 3 weeks
- DRUG
-
albumin-bound paclitaxel
albumin-bound paclitaxel 260mg/m2,day 1 of every 3 weeks
- DRUG
-
Nedaplatin
Nedaplatin 80mg/m2,day 1 of every 3 weeks
Sponsors & Collaborators
-
The First Affiliated Hospital of Xiamen University
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-07-30
- Primary Completion
- 2025-12-31
- Completion
- 2026-12-31
More Related Trials
-
Study of Tislelizumab Combined With Chemoradiotherapy and Surgery for Unresectable Esophageal Squamous Cell Carcinoma
NCT07039162 ·Status: RECRUITING ·Phase: PHASE2
-
Study of Tislelizumab in Participants With Resectable Esophageal Squamous Cell Carcinoma
NCT04974047 ·Status: COMPLETED ·Phase: PHASE2
-
Chemoradiation Plus Tislelizumab for Conversion Therapy of Locally Nonresectable ESCC
NCT05394415 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Tislelizumab as Single-Agent Neoadjuvant Immunotherapy in Resectable Esophageal Squamous Cell Carcinoma
NCT06692270 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Tislelizumab Combined With Chemotherapy or Radiotherapy in the Treatment of Advanced or Recurrent Metastatic Elderly Esophageal Cancer
NCT05628610 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Adjuvant Chemotherapy in Combination With Tislelizumab in Lymph Node-Positive Esophageal Squamous Cell Carcinoma
NCT05984342 ·Status: RECRUITING ·Phase: PHASE1
-
Tislelizumab Combined with Chemotherapy and All Trans Retinoic Acid for Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma
NCT06703047 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
The Effect of Neoadjuvant Chemoimmnotherapy Combined With Node Sparing Radiotherapy for cT3N+ EC
NCT06965829 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Neo-adjuvant Immunochemotheray Versus Neo-adjuvant Chemotherapy for Resectable Esophageal Carcinoma
NCT04280822 ·Status: RECRUITING ·Phase: PHASE3
-
Efficacy and Safety of Tislelizumab and Nab-paclitaxel Combined With Low-dose Radiotherapy in Patients With Stage IVb Esophageal Squamous Cell Carcinoma
NCT05547828 ·Status: UNKNOWN ·Phase: PHASE2
-
Neoadjuvant Immunotherapy Combined With Chemotherapy Sequenced With Endoscopic Resection for Esophageal Cancer (Endosurgery-02)
NCT07317609 ·Status: RECRUITING ·Phase: PHASE1
-
Selected Chemotherapy Combined Immunotherapy Treated High Risk Patient After NCRT in Resected Locally Advanced ESCC
NCT05189730 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Tislelizumab (BGB-A317) in Combination With Chemotherapy as First Line Treatment in Participants With Advanced Esophageal Squamous Cell Carcinoma
NCT03783442 ·Status: COMPLETED ·Phase: PHASE3
-
Neoadjuvant Chemotherapy of Nimotuzumab Plus Nab-Paclitaxel in Squamous Cell Carcinoma of Esophagus
NCT02041819 ·Status: WITHDRAWN ·Phase: PHASE2
-
Neoadjuvant Immunotherapy Combined With Chemotherapy in Patients With Locally Advanced ESCC
NCT05807542 ·Status: COMPLETED ·Phase: PHASE2
-
Neoadjuvant Chemotherapy With Nab-paclitaxel Plus Cisplatin for Stage Ⅱ-Ⅲ Esophageal Cancer Patients
NCT01258192 ·Status: COMPLETED ·Phase: PHASE2
-
Carrelizumab Combined With Chemotherapy for Adjuvant Therapy of Esophageal Squamous Cell Carcinoma
NCT05637268 ·Status: UNKNOWN ·Phase: PHASE2
-
Tislelizumab With Chemotherapy or Radiation for Neoadjuvant Therapy of Esophageal Squamous Cell Carcinoma (TINES)
NCT05603065 ·Status: UNKNOWN ·Phase: PHASE4
-
A Phase II Study of Toripalimab Plus Chemotherapy and Low-Dose Radiotherapy for Neoadjuvant Therapy-Refractory Esophageal Squamous Cell Carcinoma
NCT07272291 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Nimotuzumab,Camrelizumab, and Neoadjuvant Chemotherapy(nCT) in the Treatment of Esophageal Squamous Cell Carcinoma
NCT07312578 ·Status: ENROLLING_BY_INVITATION ·Phase: PHASE2
-
A Study to Investigate Tislelizumab (BGB-A317) Versus Placebo in Combination With Concurrent Chemoradiotherapy in Participants With Localized Esophageal Squamous Cell Carcinoma
NCT03957590 ·Status: COMPLETED ·Phase: PHASE3
-
A Phase II Study of Chemoradiotherapy With Nimotuzumab in Unresectable Esophageal Cancer
NCT04207918 ·Status: COMPLETED ·Phase: PHASE2
-
Combination of Tislelizumab and Chemoradiotherapy in Esophageal Cancer (EC-CRT-002)
NCT05520619 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Optimization of Treatment Strategy for Unresectable cN3 Esophageal Squamous Cell Carcinoma
NCT06122493 ·Status: RECRUITING ·Phase: PHASE2
-
Perioperative Vs. Preoperative Chemotherapy With Surgery in the Squamous Carcinoma of Esophagus
NCT01225523 ·Status: COMPLETED ·Phase: PHASE1