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Using Novel Imaging to Rethink Diagnostic and Treatment Strategies for Polymyalgia Rheumatica

NCT07010484 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 149

Last updated 2025-10-01

No results posted yet for this study

Summary

Polymyalgia rheumatica (PMR) is the most common chronic inflammatory rheumatic disease among the elderly and is characterized by proximal extremity pain and fatigue. Treatment with prednisolone carries several significant adverse effects, and it is therefore essential to avoid unnecessary treatment. However, clinical diagnosis and even imaging such as positron emission tomography and computed tomography (PET/CT) has low diagnostic accuracy, which decrease after start of prednisolone. The purpose is to evaluate a new method to diagnose PMR with PET/CT using magnetic resonance imaging (MRI) for informing the interpretation of PET in 111 patients suspected of PMR at baseline and after 8 weeks prednisolone treatment. In addition, a treatment initiation strategy guided by clinical diagnosis combined with PET will be evaluated in 100 patients with newly diagnosed PMR.

Conditions

  • Polymyalgia Rheumatica (PMR)

Interventions

DIAGNOSTIC_TEST

PET/MRI

PET/MRI at baseline and week 8

DIAGNOSTIC_TEST

PET/CT with 18-FDG

PET/CT in patients not receiving PET/MRI

Sponsors & Collaborators

  • Randers Regional Hospital

    collaborator OTHER

  • Central Jutland Regional Hospital

    collaborator OTHER

  • Gødstrup Hospital

    collaborator OTHER

  • Svendborg Hospital

    collaborator OTHER

  • Odense University Hospital

    collaborator OTHER

  • Regionshospitalet Horsens

    collaborator OTHER

  • Kresten Krarup Keller

    lead OTHER

Principal Investigators

  • Kresten K Keller, MD, PhD · Department of Rheumatology, Aarhus University Hospital

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-21
Primary Completion
2028-08-31
Completion
2032-08-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07010484 on ClinicalTrials.gov