A Trial to Evaluate the Safety and Immunogenicity of an Investigational Vaccine for the Prevention of Yellow Fever, and of an Investigational Vaccine for the Prevention of Rabies, in Healthy Adults
NCT06998004 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 112
Last updated 2026-04-22
Summary
The purpose of this first time in humans trial is to evaluate the safety, reactogenicity and immunogenicity of AVX70120 and of AVX70481 in healthy participants.
Conditions
- Yellow Fever
- Rabies
Interventions
- BIOLOGICAL
-
AVX70120 low dose level
Low dose level of AVX70120, AstriVax' investigational vaccine for the prevention of yellow fever
- BIOLOGICAL
-
AVX70120 middle dose level
Middle dose level of AVX70120, AstriVax' investigational vaccine for the prevention of yellow fever
- BIOLOGICAL
-
AVX70120 high dose level
High dose level of AVX70120, AstriVax' investigational vaccine for the prevention of yellow fever
- BIOLOGICAL
-
AVX70481 low dose level
Low dose level of AVX70481, AstriVax' investigational vaccine for the prevention of rabies
- BIOLOGICAL
-
AVX70481 middle dose level
Middle dose level of AVX70481, AstriVax' investigational vaccine for the prevention of rabies
- BIOLOGICAL
-
AVX70481 high dose level
High dose level of AVX70481, AstriVax' investigational vaccine for the prevention of rabies
- OTHER
-
Placebo
Placebo
Sponsors & Collaborators
-
AstriVax Therapeutics
lead INDUSTRY
Study Design
- Allocation
- RANDOMIZED
- Purpose
- PREVENTION
- Masking
- QUADRUPLE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Max Age
- 40 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2024-06-16
- Primary Completion
- 2026-01-26
- Completion
- 2026-01-26
Countries
- Belgium
Study Locations
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