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Comparative Effectiveness of Different Techniques for Repeat Ablation of Atrial Fibrillation

NCT06988202 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 630

Last updated 2026-03-23

No results posted yet for this study

Summary

Atrial fibrillation (AF) is the most common type of irregular heartbeat doctors see. People with AF sometimes have a procedure called an ablation to help get their heart back into a normal rhythm. However, this treatment doesn't always work. This study is looking at whether adding an extra step to the usual ablation-specifically treating another area of the heart called the left atrial (LA) posterior wall-can help people feel better overall, compared to just repeating the standard pulmonary vein isolation ablation procedure.

Conditions

  • Atrial Fibrillation (AF)

Interventions

PROCEDURE

Pulmonary Vein Isolation (PVI) without Left Atrial Posterior Wall Isolation (PWI)

A doctor inserts a thin, flexible tube (called a catheter) through a blood vessel, usually in the groin, and guides it to the heart. Once the catheter is in place, the doctor uses pulsed field electroporation, heat (radiofrequency) or cold (cryoablation) to create small scars in the area where the pulmonary veins connect to the left atrium of the heart. These scars block the faulty electrical signals that cause AF, helping the heart maintain a normal rhythm.

PROCEDURE

Pulmonary Vein Isolation (PVI) with Left Atrial Posterior Wall Isolation (PWI)

PVI with an additional step where the doctor also isolates the back wall (posterior wall) of the left atrium.

Sponsors & Collaborators

  • Patient-Centered Outcomes Research Institute

    collaborator OTHER

  • University of Rochester

    lead OTHER

Principal Investigators

  • Johnathan Steinberg, MD · University of Rochester

  • Wojciech Zareba, MD · University of Rochester

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-18
Primary Completion
2030-01-01
Completion
2031-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06988202 on ClinicalTrials.gov