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Assessment of Non-Invasive Testing in Major Liver-Related Outcomes

NCT06986447 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 1689

Last updated 2026-03-27

No results posted yet for this study

Summary

This is a general clinical research protocol to study the clinical evaluation, investigation and long-term follow up of patients who have Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and MetALD (MASLD and increased alcohol intake), and to assess the usefulness and accuracy of non-invasive testing such as MRI and Fibroscan in tracking the progression of disease. The protocol is designed to follow the natural history, pathogenesis, interventions, treatment response, comorbidities, major liver related outcomes, and major cardiac events in patients with MASLD and MetALD, especially those with significant and advanced fibrosis. Data will be collected to help further the understanding of non-invasive testing with the hopes of lessening the need for liver biopsies in phase 3 clinical trials of MASLD and in clinical practice. Additionally, the study will aim to define the natural history of MetALD, an area that is poorly understood.

Conditions

  • Metabolic Dysfunction-Associated Steatotic Liver Disease
  • MASLD
  • MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
  • MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)
  • MetALD

Sponsors & Collaborators

  • HRI-MAIL-NIT

    lead INDUSTRY

Principal Investigators

  • Mazen Noureddin, MD, MHSc · Houston Research Institute

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-25
Primary Completion
2029-02-28
Completion
2029-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06986447 on ClinicalTrials.gov